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Purified anti-human CD102 (ICAM-2) Antibody

Pricing & Availability
Clone
CBR-IC2/2 (See other available formats)
Regulatory Status
RUO
Workshop
V BP363
Other Names
Intercellular Adhesion Molecule-2, ICAM-2
Isotype
Mouse IgG2a, κ
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Product Citations
publications
CBRIC2_2_Pure_072808.jpg
Human peripheral blood lymphocytes stained with purified CBRIC2/2, followed by anti-mouse IgG FITC
  • CBRIC2_2_Pure_072808.jpg
    Human peripheral blood lymphocytes stained with purified CBRIC2/2, followed by anti-mouse IgG FITC
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328502 100 µg $112
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Description

CD102 is a 55 kD type I transmembrane glycoprotein, belongs to immunoglobulin superfamily, also known as Intercellular Adhesion Molecule-2, or ICAM-2. CD102 is constitutively expressed on vascular endothelial cells, some lymphocytes, monocytes, and platelets. CD102 is thought to be involved in lymphocyte recirculation and in costimulation of immune response. CD102 is a counter receptor of LFA-1 (CD11a/CD18), DC-SIGN and MAC-1.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
ICAM-2 cDNA transfected COS cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP, IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications: immunoprecipitation(1), blocking the interaction between ICAM-2 and LFA-1(1), immunohistochemical staining(2) of frozen tissue sections

Application References

(PubMed link indicates BioLegend citation)
  1. DeFougerolles AR,et al.1991.J. Exp.Med.174:253.
  2. Van Herpen CML,et al.2005.Clin. Cancer Res.11:1899
Product Citations
  1. Kim N, et al. 2020. Cancers (Basel). 12:. PubMed
RRID
AB_1134245 (BioLegend Cat. No. 328502)

Antigen Details

Structure
55 kD type I transmembrane glycoprotein, Ig superfamily
Distribution

Vascular endothelial cells, lymphocytes, monocytes, platelets

Function
Adhesion, costimulation
Ligand/Receptor
LFA-1, DC-SIGN, MAC-1
Cell Type
Endothelial cells, Lymphocytes, Monocytes, Platelets
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1.Weber KSC, et al.2004.Inflammation.28:177.
2.Barclay A, et al.1997 The Leukoycte Antigen FactsbookAcademic Press.
3. Casasnovas JM, et al.1999.P. Natl. Acad. Sci. USA96:3017.
4. Diamonds MS, et al.1990. J. Cell Biol.111:3129.

Gene ID
3384 View all products for this Gene ID
UniProt
View information about CD102 on UniProt.org
Go To Top Version: 2    Revision Date: 08/25/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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