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Purified anti-human CD108 Antibody

Pricing & Availability
Clone
KS-2 (See other available formats)
Regulatory Status
RUO
Other Names
CD108, Semaphorin 7A
Isotype
Mouse IgG2a, κ
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Product Citations
publications
KS2_PURE_CD108_Antibody_030322
PHA stimulated (3 days) human peripheral blood lymphocytes were stained with purified anti-human CD108 (clone KS-2) (filled histogram) or mouse IgG2a, κ isotype control (open histogram) followed by PE anti-mouse IgG2a.
  • KS2_PURE_CD108_Antibody_030322
    PHA stimulated (3 days) human peripheral blood lymphocytes were stained with purified anti-human CD108 (clone KS-2) (filled histogram) or mouse IgG2a, κ isotype control (open histogram) followed by PE anti-mouse IgG2a.
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376602 100 µg $317
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Description

CD108 is an 80 kD GPI-linked membrane-bound semaphorin, also known as the John-Milton-Hagen (JMH) blood group antigen, semaphorin 7A, H-SEMA, and SEMAL. It contains an Ig-like domain and is expressed at low levels on erythrocytes and lymphocytes. The expression of CD108 on lymphocytes is upregulated upon activation, and it plays an important role in modulating inflammation and T-cell-mediated immune responses. CD108 is a guidance protein that is involved in central and peripheral axon growth. The interaction of CD108 with its receptor PlexinC1 induces activation of monocytes.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
PHA-activated PBMC
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. New York.
  2. Angelisova P, et al. 1999. Immunobiology 200:234-45.
RRID
AB_2910429 (BioLegend Cat. No. 376602)

Antigen Details

Structure
Membrane-bound semaphorin with GPI linkage and contains and IgG like domain, approximately 80kD
Distribution

Widely expressed in spleen, thymus, testis, ovary, heart, lung, kidney, brain, small intestine, red cells, monocytes, and T cells

Function
Modulates inflammation and T-cell-mediated immune responses. Guidance protein involved in central and peripheral axon growth. Interaction with PlexinC1 induces activation of monocytes.
Ligand/Receptor
PlexinC1
Cell Type
Erythrocytes, Monocytes, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Mine, T, et al. 2000. Tissue Antigens. 55: 429–36.
  2. Jeroen Pasterkamp, et al. 2003. Nature. 424:398-405.
  3. Seltsam A, et al. 2007. Transfusion. 47:133-46.
  4. Suzuki K, et al. 2007. Nature. 446:680-4.
Gene ID
8482 View all products for this Gene ID
UniProt
View information about CD108 on UniProt.org
Go To Top Version: 1    Revision Date: 03/03/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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