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- Clone
- 24 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- ILT1, LIR-7, LILRA2
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes stained with purified clone 24, followed by anti-mouse IgG biotin and Sav-PE
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 337902 | 100 µg | $229 | ||||
CD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). It is composed of both activating and inhibitory isoforms. The activating subset of ILTs is characterized by containing short cytoplasmic domains and positively charged arginine residues, while the inhibitory isoforms display long cytoplasmic tails containing ITIM motifs. CD85h is a 69kD activating receptor, also known as ILT1, LIR-7, or LILRA2. ILT1 is found on the surface of monocytes/macrophages, dendritic cells, and at relatively low levels on granulocytes. It is also expression on a small subset of NK cells. ILT1 acts as an activating receptor through its association with Fc receptor γ chain.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
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Additional reported applications include: immunohistochemical staining of acetone-fixed frozen tissue sections, Costimulation and activation of myeloid cells skewing of dendritic cell differentiation
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Application References
(PubMed link indicates BioLegend citation) -
- Lee DJ, et al. 2007 J. Immunol. 179 8128.
- RRID
-
AB_1279313 (BioLegend Cat. No. 337902)
Antigen Details
- Structure
- ILT/LIR family, Ig superfamily, 69 kD glycoprotein
- Distribution
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Monocytes/macrophages, dendritic cells, granulocytes (low), small subset of NK cells
- Ligand/Receptor
- Associate with Fc receptor γchain
- Cell Type
- Dendritic cells, Granulocytes, Macrophages, Monocytes, NK cells, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
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1. Tedla N, et al. 2003. Proc. Natl. Acad. Sci. 100:1174
2. Nakajima H, et al. 1999. J. Immunol. 162:5 - Gene ID
- 11027 View all products for this Gene ID
- UniProt
- View information about CD85h on UniProt.org
Related FAQs
Other Formats
View All CD85h Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD85h (ILT1) | 24 | FC |
| PE anti-human CD85h (ILT1) | 24 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD85h (ILT1)
Human peripheral blood monocytes stained with purified clone... -
PE anti-human CD85h (ILT1)
Human peripheral blood monocytes stained with clone 24 PE
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