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Purified anti-human CD87 Antibody

Pricing & Availability
Clone
VIM5 (See other available formats)
Regulatory Status
RUO
Workshop
VI MR13
Other Names
Urokinase plasminogen activator-receptor, uPA-R, uPAR
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
VIM5_Pure_021009.jpg
Human peripheral blood granulocytes stained with purified VIM5, followed by anti-mouse IgG FITC
  • VIM5_Pure_021009.jpg
    Human peripheral blood granulocytes stained with purified VIM5, followed by anti-mouse IgG FITC
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336902 100 µg $114
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Description

CD87, known as urokinase plasminogen activator-receptor (uPAR), is a 36-68 kD single-chain glycophosphotidylinositol (GPI)-anchored glycoprotein. The extracellular region of CD87 consists of three homologous domains, D1, D2, and D3. Membrane-bound and soluble (D2D3) forms of uPAR have been reported. The membrane-bound CD87 is expressed on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. CD87 plays a role in cell adhesion and chemotaxis through binding to β1, β2 and β3 integrins. CD87-bound uPA converts plasminogen to plasmin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
THP-1 (human myeloid cell line)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications include: VIM5 mAb binds to uPA binding-domain

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossmant SF, et al. eds. 1995 Leukocyte Type V. Oxford University Press Inc, New York
  2. Gadd SJ, et al. 1990. Clin. Exp. Immunol 80:252
  3. Sillaber C, et al. 1997. J. Biol. Chem. 272:7824
Product Citations
  1. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
RRID
AB_2165470 (BioLegend Cat. No. 336902)

Antigen Details

Structure
Glycophosphotidylinositol (GPI)-anchored glycoprotein, 36-68 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes.

Function
Convert plasminogen to plasmin, cell adhesion, chemotaxis
Ligand/Receptor
Urokinase plasminogen activator (uPA), vitronectin, β1, β2 and β3 integrins, kininogen
Cell Type
Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Beaufort N, et al. 2004. J. Immunol. 172:540
2. Tarui T, et al. 2001. J. Bio. Chem. 276:3983
3. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. A John Wiley & Sons Inc, Publication

Gene ID
5329 View all products for this Gene ID
UniProt
View information about CD87 on UniProt.org
Go To Top Version: 2    Revision Date: 09/01/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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