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- Clone
- HM7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FcμR, FcmR, Fc mu receptor, IgM Fc receptor, FAIM3, TOSO
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with FcμR (FAIM3) (clone HM7) Purified (left) or Mouse IgG2b, κ Purified isotype control (right) followed by PE anti-mouse IgG. Cells were then stained with CD19 PerCP/Cyanine5.5.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 398102 | 100 µg | $329 | ||||
The human FCMR (also known as FcμR, FAIM, TOSO) is a type 1 transmembrane glycoprotein that belonging to the immunoglobulin (Ig) gene superfamily. FCMR had a molecular weight of ~60 kD. Human FCMR is predominantly expressed by B, T, and NK cells, but not by monocytes, granulocytes, erythrocytes, and platelets. FCMR may play roles in regulating humoral immune responses.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- BW5147 cells expressing human FCMR protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Application Notes
-
It was reported that HM7 antibody can block binding of human IgM to FCMR.
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Application References
(PubMed link indicates BioLegend citation) -
- Kubagawa H, et al. 2009. J Exp Med. 206(12): 2779-93.
- Kubagawa H, et al. 2014. Monoclon Antib Immunodiagn Immunother. 33(6): 393– 400.
- RRID
-
AB_2814380 (BioLegend Cat. No. 398102)
Antigen Details
- Structure
- ~60 kD transmembranesialoglycoprotein extracellular Ig-like domain
- Distribution
-
B and T lymphocytes, natural killer (NK) cells, chronic lymphocytic leukemia cells, some lymphoid leukemia or lymphoma cell lines
- Function
- Regulates both the cell surface expression and the function of BCR, regulates humoral immune responses
- Ligand/Receptor
- IgM Fc
- Cell Type
- B cells
- Biology Area
- Adaptive Immunity, Immunology, Signal Transduction
- Molecular Family
- Fc Receptors
- Antigen References
-
- Kubagawa H, et al. 2009. J Exp Med. 206(12): 2779-93.
- Shima H, et al. 2010. Int Immunol. 22(3): 149-56.
- Kubagawa H, et al. 2019. Front Immunol. 10:945.
- Meryk A, et al. 2019. Cell Rep. 26(10): 2681-91.
- Liu J, et al. 2019. Front Immunol. 10:529.
- Gene ID
- 9214 View all products for this Gene ID
- UniProt
- View information about Fc muR on UniProt.org
Related FAQs
Other Formats
View All FcμR Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human FcμR (FAIM3) | HM7 | FC |
| APC anti-human FcµR (FAIM3) | HM7 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human FcμR (FAIM3)
Human peripheral blood lymphocytes were stained with FcμR (F... -
APC anti-human FcµR (FAIM3)
Human peripheral blood lymphocytes were stained with APC ant...
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