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- Clone
- K102B9 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FMLPY, FPRH2, formyl peptide receptor like 2, FPR3, formyl peptide receptor 3
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
FPRL2 transfected CHO cells (top) or human peripheral blood monocytes (bottom) were stained with purified FPRL2 (clone K102B9, filled histograms) or mouse IgG2a, κ isotype control (open histograms), followed by anti-mouse IgG PE. -
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 357702 | 100 µg | $265 | ||||
FPR3, also known as FPRL2, belongs to the formyl peptide receptor family which includes FPR1, FPR2, and FPR3. Monocytes express FPR1, 2, and 3; upon differentiation into macrophages, expression of these receptors is maintained. Two ligands, humanin and F2L have been identified. Humanin is expressed in the heart, skeletal muscle, kidney, and liver but is not expressed in the immune system. F2L is a heme-binding protein first identified in the spleen. Binding of FPRL2 and F2L induces Ca2+ mobilization and neutrophil chemotaxis. Low level of expression of FPRL2 has also been reported on NK cells.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- DNA vaccine containing full length FPRL2.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2561982 (BioLegend Cat. No. 357702)
Antigen Details
- Structure
- 40 kD, seven transmembrane protein
- Distribution
- Monocytes, macrophages, basophils, plasmacytoid dendritic cells
- Function
- Neutrophil chemotaxis and degranulation
- Ligand/Receptor
- Humanin and FPRL2 ligand (F2L)
- Cell Type
- Monocytes, Macrophages, Basophils, Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Antigen References
-
1. Devosse T, et al. 2009. J. Immunol. 182:4974.
2. Yang D, et al. 2002. J. Leukoc. Biol. 72:598.
3. Harada M, et al. 2004. Biochem. Biophys. Res. Commun. 324:255.
4. Migeotte I, et al. 2005. J. Exp. Med. 201:83.
5. Gao JL, et al. 2007. J. Immunol. 178:1450. - Gene ID
- 2359 View all products for this Gene ID
- UniProt
- View information about FPR3 on UniProt.org
Related FAQs
Other Formats
View All FPR3 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human FPR3 (FPRL2) | K102B9 | FC |
| PE anti-human FPR3 (FPRL2) | K102B9 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human FPR3 (FPRL2)
FPRL2 transfected CHO cells (top) or human peripheral blood ... 
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PE anti-human FPR3 (FPRL2)
FPRL2 transfected CHO cells (top) or human peripheral blood ... 
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