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- Clone
- HY101 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Platelet glycoprotein VI, GPVI
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human peripheral blood platelets were stained with anti-human CD41 APC and purified anti-human GP6 (clone HY101) (left) or with purified anti-mouse IgG1, κ isotype control (right), followed by PE goat anti-mouse IgG.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 383802 | 100 µg | $248 | ||||
Glycoprotein VI (GPVI) is a 37 kD type-I transmembrane glycoprotein of the immunoglobulin superfamily, primarily expressed on platelets and megakaryocytes. GPVI is a collagen receptor and is involved in collagen-induced platelet adhesion and activation. GPVI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Glycoprotein VI transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
Agonist, WB - Reported in the literature, not verified in house - Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Chen, H, et al. 2001. J Biol chem. 277: 3011-3019. (FC, WB)
- van Dievoet, M, et al. 2022. Platelets. 1,17:1-4. (Agonist)
- RRID
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AB_2924586 (BioLegend Cat. No. 383802)
Antigen Details
- Structure
- Type-I transmembrane glycoprotein, 37 kD, member of the immunoglobulin superfamily,
- Distribution
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Megakaryocytes, Platelets
- Function
- Platelet adhesion and activation, blood coagulation, and hemostasis
- Interaction
- FcR gamma-chain, Src kinases, SYK, LAT
- Ligand/Receptor
- Collagen
- Gene ID
- 51206 View all products for this Gene ID
- UniProt
- View information about GP6 on UniProt.org
Related FAQs
Other Formats
View All GP6 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human GP6 | HY101 | FC,Agonist,WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human GP6
Human peripheral blood platelets were stained with anti-huma...
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