- Clone
- N1/12 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- SLC12A5, rKCC2, K-Cl cotransporter 2, neuronal K-Cl cotransporter, solute carrier family 12, member 5, neuronal-specific K-Cl cotransporter, furosemide-sensitive K-Cl cotransporter, electroneutral potassium-chloride cotransporter 2
- Previously
-
Covance Catalog# MMS-5241
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
821701 | 100 µL | $165 |
Potassium-chloride cotransporter member 5 (also known as KCC2 and SCL12A5) is responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations. Mediates synaptic inhibition, protects against excitotoxicity and modulates plasticity.
Product DetailsProduct Details
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against a fusion protein corresponding to amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b.
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 10.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration of 10.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2564853 (BioLegend Cat. No. 821701)
Antigen Details
- Structure
- Expected MW: 140 kD
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Postsynaptic proteins
- Gene ID
- 171373 View all products for this Gene ID
- UniProt
- View information about KCC2 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All KCC2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-KCC2 | N1/12 | WB,IHC |
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