- Clone
- M1606B04 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Mac-2, Gal-3, RL-29, galactose-specific lectin 3, CBP-35, L-34, εBP
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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677301 | 50 µg | $71 | ||||
677302 | 500 µg | $258 |
Galectin-3 (galactose-specific lectin 3) is a unique member of the β-galactoside-binding lectin family molecule, which plays an important role in regulation of cell proliferation, differentiation, and tumor cell metastasis. Galectin-3 is mainly found in the cytoplasm, but it is also seen in the nucleus and can be secreted by the non-classical, secretory pathway. In general, secreted galectin-3 mediates cell migration, cell adhesion, and cell-cell interactions through its high affinity binding with galactose-containing glycoproteins on the cell surface. Cytoplasmic galectin-3 exhibits anti-apoptotic activity and regulates several signal transduction pathways, whereas nuclear galectin-3 has been associated with pre-mRNA splicing and gene expression. Recent studies also indicate the potential role of galectin-3 as a biomarker for acute and chronic heart failure.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant full-length human Galectin-3.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IP - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunoprecipitation, the suggested use of this reagent is 1-5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2565901 (BioLegend Cat. No. 677301)
AB_2565901 (BioLegend Cat. No. 677302)
Antigen Details
- Structure
- 250 amino acids with a predicted molecular weight of approximately 26 kD.
- Distribution
-
Localized in the nucleus, cytoplasm, cell surface, or extracellular matrix. Expressed by tumor cells, monocytes/macrophages, epithelial cells, Kupffer cells, and dendritic cells.
- Function
- Regulate cell proliferation, differentiation, adhesion, and anti-apoptosis.
- Interaction
- DMBT1, ITGA3, ITGB1, CSPG4, LGALS3BP, LYPD3, CYHR1, and UACA.
- Ligand/Receptor
- Variety of ligands such as IgE, IgA, galactose, casein kinase I, laminin, mucin, LAMPs, CD66, and etc.
- Cell Type
- Dendritic cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Immunology, Signal Transduction, Transcription Factors
- Molecular Family
- Adhesion Molecules
- Antigen References
-
1. Kim HR, et al. 1999. Cancer Res. 16:4148.
2. Reljic R, et al. 2004. Immunol. Lett. 93:51.
3. Takenaka Y, et al. 2004. Mol. and Cell. Biol. 24:4395.
4. Joo HG, et al. 2001. J Leuko. Biol. 4:555.
5. Gudowska M, et al. 2014. Pol. Merkur. Lekarski. 37:348.
6. Xin M, et al. 2015. Biomed. Pharmacother. 69:179.
7. Filipe MD, et al. 2015. Clin. Chim. Acta. 443:48.
8. Funasaka T, et al. 2014. Glycobiology 24:886. - Gene ID
- 3958 View all products for this Gene ID
- UniProt
- View information about Mac-2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Mac-2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Mac-2 (Galectin-3) | M1606B04 | WB,IP |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-Mac-2 (Galectin-3)
Cell lysate from HepG2 (lane 1), A549 (lane 2), PC3 (lane 3)...
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