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- Clone
- N75/3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GRM1, mGluR1, GRM1/5
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot of Purified anti-mGluR1 antibody (clone N75/3). Lane 1, 5: Molecular weight marker; Lane 2, 6: 40µg of human brain lysate; Lane 3, 7: 20µg of mouse brain lysate; Lane 4, 8: 20 µg of rat brain lysate. The blots were incubated with 5 µg/mL of the primary antibody or mouse IgG1 isotype control overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 861701 | 25 µg | $83 | ||||
| 861702 | 100 µg | $165 | ||||
Glutamate Metabotropic Receptor 1, also known as GRM1, is a G protein-coupled receptor that belongs to the group 1 metabotropic glutamate receptor family (mGluR1). GRM1 is an excitatory neurotransmitter receptor involved in hippocampal long-term potentiation and cerebellar long-term depression as demonstrated in an in vivo mouse knockout model of GRM1.These animals also display impaired motor function despite normal brain structure and anatomy compared to their wild type littermates.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone detects both monomer and dimer of GRM1.
- RRID
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AB_2801231 (BioLegend Cat. No. 861701)
AB_2801231 (BioLegend Cat. No. 861702)
Antigen Details
- Structure
- GRM1 is a 1194 amino acid protein with an apparent molecular mass of ~ 133 kD.
- Distribution
-
Tissue Distribution: Brain
Cellular Distribution: Plasma membrane - Function
- GRM1 is a glutamate receptor that regulates synaptic plasticity.
- Interaction
- Homodimer, HOMER1, HOMER2, HOMER3, SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3, GRASP
- Ligand/Receptor
- Glutamate
- Cell Type
- Neurons
- Biology Area
- Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Neurotransmitter Receptors, Postsynaptic proteins
- Antigen References
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- Foster DJ and Conn PJ. 2017. Neuron. 94:431
- Dravolina OA, et al. 2017. Psychopharmacology (Berl). 234(9-10):1333
- Bray N. 2016. Nat Rev Neurosci. 17(10):603
- Gene ID
- 2911 View all products for this Gene ID 14816 View all products for this Gene ID 24414 View all products for this Gene ID
- UniProt
- View information about mGluR1 on UniProt.org
Other Formats
View All mGluR1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mGluR1 | N75/3 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mGluR1
Western blot of Purified anti-mGluR1 antibody (clone N75/3)....
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