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Purified anti-mouse CD182 (CXCR2) Antibody

Pricing & Availability
Clone
SA045E1 (See other available formats)
Regulatory Status
RUO
Other Names
IL-8RB, GRO/MGSA, Cmkar2
Isotype
Rat IgG2a, κ
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Product Citations
publications
SA045E1_Purified_CD182_Antibody_FC_1_021815
C57BL/6 mouse bone marrow cells were stained with purified CXCR2 (clone SA045E1, top) or purified rat IgG2a, κ isotype control (bottom), followed by anti-rat IgG PE, and was posteriorly costained with Ly-6G/Ly-6C APC.
  • SA045E1_Purified_CD182_Antibody_FC_1_021815
    C57BL/6 mouse bone marrow cells were stained with purified CXCR2 (clone SA045E1, top) or purified rat IgG2a, κ isotype control (bottom), followed by anti-rat IgG PE, and was posteriorly costained with Ly-6G/Ly-6C APC.
  • SA045E1_Purified_CD182_Antibody_FC_2_021815
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149602 100 µg $265
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Description

CD182, also known as CXCR2, is a G-protein coupled receptor with seven transmembrane regions that is involved in chemotaxis, neutrophil activation, and angiogenesis. CXCR2 is expressed by neutrophils, basophils, a subset of T cells, monocytes, macrophages, natural killer (NK) and natural killer T cells (NKT). Its ligands are CXCL1, CXCL2, CXCL3, and CXCL5.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CXCR2-transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
RRID
AB_2565307 (BioLegend Cat. No. 149602)

Antigen Details

Structure
G-protein coupled receptor and seven transmembrane regions.
Distribution

Neutrophils, basophils, subset of T cells, monocytes, macrophages, and natural killer (NK) cells.

Function
Chemotaxis, neutrophil activation, and angiogenesis.
Ligand/Receptor
CXCL1, CXCL2, CXCL3, and CXCL5.
Cell Type
Basophils, Macrophages, Monocytes, Neutrophils, NK cells, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Spaan AN, et al. 2014. Nat. Commun. 5:5438.
2. Natsuaki Y, et al. 2014. Nat. Immunol. 15:1064.
3. Hsieh CY, et al. 2014. J. Immunol. 193:3693.
4. Diana J and Lehuen A. 2014. EMBO Mol. Med. 6:1090.
5. Stoolman JS, et al. 2014. J. Immunol. 193:564.

Gene ID
12765 View all products for this Gene ID
UniProt
View information about CD182 on UniProt.org
Go To Top Version: 1    Revision Date: 02/18/2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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