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Purified anti-mouse CD198 (CCR8) Antibody

Pricing & Availability
Clone
SA214G2 (See other available formats)
Regulatory Status
RUO
Other Names
CDw198, C-C chemokine receptor type 8, CKR-8, CC-CKR-8, Ter1
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
SA214G2_PURE_CCR8_Antibody_FC_1_102715
C57BL/6 mouse thymocytes were stained with purified CCR8 (clone SA214G2, top) or purified rat IgG2b, κ isotype control (bottom), followed by anti-rat IgG-PE and then by CD8 APC.
  • SA214G2_PURE_CCR8_Antibody_FC_1_102715
    C57BL/6 mouse thymocytes were stained with purified CCR8 (clone SA214G2, top) or purified rat IgG2b, κ isotype control (bottom), followed by anti-rat IgG-PE and then by CD8 APC.
  • SA214G2_PURE_CCR8_Antibody_FC_2_102715
  • SA214G2_PURE_CCR8_Antibody_FC_3_102715
    Murine T-cell lymphoma cell line BW5147.3 was stained with purified CCR8 (clone SA214G2, filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG-PE.
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150302 100 µg $241
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Description

C-C chemokine receptor type 8 (CCR8) CD198, is a 41 kD G-protein coupled receptor with 7 transmembrane regions. CCR8 is expressed by a subset of thymocytes, Tregs, NKT and Th2-polarized cells, a subset of macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 mediates chemotaxis toward its ligand CCL1, and is involved in apoptosis of thymocytes.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CD198 (CCR8)-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
RRID
AB_2566246 (BioLegend Cat. No. 150302)

Antigen Details

Structure
G-protein coupled receptor, 7 transmembrane regions, 41 kD.
Distribution

Thymocytes, Tregs, NKT and Th2-polarized cells, subset of macrophages, monocytes and monocyte-derived dendritic cells.

Function
Chemotaxis, involved in thymocyte apoptosis
Ligand/Receptor
CCL1 (SCY1,TCA-3)
Cell Type
Dendritic cells, Macrophages, Monocytes, NKT cells, Th2, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Coghill JM, et al. 2013. Blood. 122:825.
2. Islam SA, et al. 2011. Nat. Immunol. 12:167.
3. Hoshino A, et al. 2007. J. Immunol. 178:5296.
3. Qu C, et al. 2004. J. Exp. Med. 200:1231.

Gene ID
12776 View all products for this Gene ID
UniProt
View information about CD198 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12/16/2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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