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Purified anti-mouse/human CD207 (Langerin) Antibody

Pricing & Availability
Clone
4C7 (See other available formats)
Regulatory Status
RUO
Other Names
CLEC4K
Isotype
Mouse IgG2a, κ
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Product Citations
publications
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144201 25 µg $94
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144202 100 µg $270
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Description

CD207, also known as langerin, is a 40 kD single-pass type II transmembrane protein, member of the C-type lectin family. CD207 is expressed on the cell surface and Birbeck granules (BGs) of Langerhans cells, and subsets of thymic and splenic dendritic cells. Its ligands are mannose, n-acetylglucosamine, fucose, and sulfated glycans. Langerin is involved in the antigen processing pathway through capture and internalization of its ligands.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse, Human
Reported Reactivity
Cynomolgus, Rabbit, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Langerin extracellular domain-Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed
  2. Kubick BJ, et al. 2020. J Invest Dermatol. 140:891. PubMed
RRID
AB_2562087 (BioLegend Cat. No. 144201)
AB_2562087 (BioLegend Cat. No. 144202)

Antigen Details

Structure
Single-pass type II transmembrane protein, 40 kD, one C-type lectin domain, homotrimer
Distribution

Langerhans cells, subsets of thymic and splenic dendritic cells

Function
Antigen uptake, antigen processing
Ligand/Receptor
Mannose, n-acetylglucosamine, fucose, sulfated glycans
Cell Type
Dendritic cells, Langerhans cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Romani N, et al. 2012. Curr. Top. Microbiol. Immunol. 351:113.
2. Kaplan DH. 2010. Trends Immunol. 31:446.
3. Clausen BE and Kel JM. 2010. Immunol. Cell. Biol. 88:351.
4. Merad M, et al. 2008. Nat. Rev. Immunol. 8:935.

Gene ID
246278 View all products for this Gene ID 50489 View all products for this Gene ID
UniProt
View information about CD207 on UniProt.org
Go To Top Version: 3    Revision Date: 08/22/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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