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Purified anti-mouse IL-25 (IL-17E) Antibody

Pricing & Availability
Clone
35B (See other available formats)
Regulatory Status
RUO
Other Names
IL-17E
Isotype
Rat IgG1, κ
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514401 50 µg $136
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Description

IL-25 (IL-17E) is a member of the IL-17 family of proinflammatory cytokines which include at least six members including IL-17A (IL-17), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17E is found at low levels in various peripheral tissues. It is a proinflammatory cytokine that promotes airway eosinophilia in mice. IL-17E plays a role in Th2 type inflammatory diseases, such as asthma and atopic dermatitis.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
IL-25
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA - Quality tested
Neut - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Neutralization: The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-25 bioactivity (Cat. No. 514417).

Application References

(PubMed link indicates BioLegend citation)
  1. Angkasekwinai P, et al. 2007. J. Exp Med. 204:1509.
RRID
AB_2043954 (BioLegend Cat. No. 514401)

Antigen Details

Structure
Cytokine; 19 kD
Bioactivity
Induce proinflammatory responses, promote the expression of the prototypical Th2 genes
Cell Sources
Activated Th2 cells, bone marrow-derived mast cells, and alveolar macrophages
Cell Targets
IL-17RB mRNA transcripts are abundantly expressed in the kidney and liver and at lower levels in the testes, brain, small intestine, and other organs.
Receptors
IL-17BR (EVI27, IL17Rh1)
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fort MM, et al. 2001. Immunity 15:985.
2. Lee J, et al. 2001. J. Biol Chem. 276:1660.
3. Hurst SD, et al. 2002. J. Immunol. 169:443.
4. Kleinschel MA, et al. 2007. J. Exp. Med. 204:161.

Gene ID
140806 View all products for this Gene ID
UniProt
View information about IL-25 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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