- Clone
- W18163A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Sestrin 2, Sestrin-2, SEST2, SES2
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
937601 | 25 µg | $101 | ||||
937602 | 100 µg | $253 |
Sestrin 2 (SESN2) is part of the sestrin family of evolutionally conserved stress inducible proteins. SESN2 plays a role in cell growth and survival by protecting cells against oxidative and genotoxic stress. SESN2 reduces oxidative stress by activating Nrf2 and inhibits mTOR activation through AMPK. SESN2 is an intracellular leucine sensor which negatively regulates protein translation in response to ER stress by interacting with the TORC1 signaling pathway through GATOR2. SESN1 is a paralog of SESN2. Diseases associated with SESN2 include nodular ganglioneuroblastoma and pulmonary emphysema.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Partial recombinant human SESN2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IP - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.125 - 1 µg/mL. For immunoprecipitation, the suggested use of this reagent is 2.5 µg/test. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone recognizes human and mouse SESN2.
Clone does not work for ICC. - RRID
-
AB_2876754 (BioLegend Cat. No. 937601)
AB_2876754 (BioLegend Cat. No. 937602)
Antigen Details
- Structure
- SESN2 is a 480 amino acid protein with a predicted molecular weight of 54.5 kD. Western blot shows a band around 56 kD.
- Distribution
-
SESN2 is primarily localized to the cytosol
- Function
- Gene expression, stress response
- Interaction
- GATOR2, AMPK, Nrf2
- Antigen References
-
- Bodmer D and Soledad LH. 2017. Cell Death & Dis. 8(10):e3068.
- Kim MJ, et al. 2016. Autophagy. 8:1272.
- Zhao B, et al. 2017. Photochem Photobiol. 1:375-81
- Maiuri MC, et al. 2009. Cell Cyc. 10:1571.
- Gene ID
- 83667 View all products for this Gene ID
- UniProt
- View information about SESN2 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All SESN2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-SESN2 | W18163A | WB,IP |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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