- Clone
- W18298A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3, Syp, Protein Tyrosine Phosphatase Non-Receptor Type 11, SH2 Domain-Containing Protein Tyrosine Phosphatase 2
- Isotype
- Rat IgG2a, λ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
609251 | 25 µg | $139 | ||||
609252 | 100 µg | $368 |
Src homology-2-containing protein tyrosine phosphatase 2 (SHP-2) protein, encoded by the PTPN11 gene, is a well-known oncogenic protein tyrosine phosphatase. SHP-2 regulates cellular functions by dephosphorylating targets downstream of PD1, EGFRvIII, HGF receptor, and cytokine receptors. Cellular processes controlled by SHP-2 include mitotic cycle, cell growth, differentiation, and oncogenesis. SHP-2 has been recognized as a potential therapeutic target for cancers including breast cancer, lung cancer, leukemia, gastric cancer, and oral cancer.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant fragment of human SHP-2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This product cross reacts with mouse cell lines in Western-blot application but has poor selectivity. Clone A20016A is recommended for mouse reactivity.
This product is not recommended for immunocytochemistry. - RRID
-
AB_2927989 (BioLegend Cat. No. 609251)
AB_2927989 (BioLegend Cat. No. 609252)
Antigen Details
- Structure
- SHP-2 is a 593 amino acid protein with a molecular mass of 68 kD
- Distribution
-
Cytoplasm and Nucleus
- Function
- SHP-2 regulates cell proliferation, apoptosis, invasion, and metastasis
- Interaction
- SHP-2 interacts with PD1, EGFR, HGF receptor, RET, FGFR2, FGFR3, PI3K/AKT, and TLR3 signaling pathways.
- Cell Type
- Lymphocytes, T cells, Th1
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Immuno-Oncology, Immunology
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
-
- Hao C, et al. 2020. Oncogene. 39:7166-7180.
- Marie D, et al. 2008. Cell Signal. 20:453-9.
- Cheng Kui QU. 2000. Cell Research. 10:279-288.
- Gene ID
- 5781 View all products for this Gene ID
- UniProt
- View information about SHP-2 on UniProt.org
Other Formats
View All SHP-2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-SHP-2 | W18298A | WB,IHC-P |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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