- Clone
- TDP2H4 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TAR DNA-binding protein-43, TDP 43, TARDBP, ALS10
- Previously
-
Covance Catalog# SIG-39854
- Isotype
- Rat IgG2a
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
808301 | 100 µL | $370 |
TDP43, also known as TARDBP, was originally identified as a protein that binds to the transactivation response (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome. TDP43 contains two copies of a ~90 amino acid RNA recognition motif (RRM) found in many proteins, which bind single stranded RNA. Recent research has shown that hyperphosphorylated, ubiquitinated, and N-terminally truncated TDP43 is the pathological hallmark lesion in most familial and sporadic forms of FTLD-U and ALS (1).
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- This antibody was raised against a nonphosphorylated peptide corresponding to the C-terminal domain of human TDP43, which includes serine residues 409 and 410.
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1.0 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
IHC-P - Quality tested
WB, Direct ELISA - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a dilution of 1:500 is suggested. For Western blotting, the suggested use of this reagent is 1.0 – 5.0 µg per ml. For Direct ELISA application, a concentration range of 10 ng - 1.0 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody is effective in immunoblotting (WB), immunohistochemistry (IHC), and Direct ELISA.
Expected Staining Pattern: Nuclear -
Application References
(PubMed link indicates BioLegend citation) -
- Neumann M. 2009. Int. J. Mol. Sci. 10.3390/ijms10010232.
- RRID
-
AB_2564740 (BioLegend Cat. No. 808301)
Antigen Details
- Structure
- TDP43 is a 414 amino acid protein with an apparent molecular mass of 45 kD.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- TDP43
- Gene ID
- 23435 View all products for this Gene ID 230908 View all products for this Gene ID 298648 View all products for this Gene ID
- UniProt
- View information about TDP43 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All TDP43 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-TDP43 | TDP2H4 | IHC-P,WB,Direct ELISA |
Biotin anti-TDP43 | TDP2H4 | WB,IHC-P |
Customers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-TDP43
IHC staining of anti-TDP43 antibody (clone TDP2H4) on formal... Western blot of anti-TDP43 antibody (clone TDP2H4). Lane 1: ... Western blot of anti-TDP43 antibody (clone TDP2H4). Lane 1: ... Direct ELISA of purified anti-TDP43 antibody (clone TDP2H4) ... -
Biotin anti-TDP43
Western blot of Biotin anti-TDP43 antibody (clone TDP2H4). L... IHC staining of Biotin anti-TDP43 antibody (clone TDP2H4) on... IHC staining of Biotin anti-TDP43 antibody (clone TDP2H4) on...
Follow Us