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Purified anti-TIMP-1 Antibody

Pricing & Availability
Clone
F31P2A5 (See other available formats)
Regulatory Status
RUO
Other Names
TIMP1, EPA, Collagenase inhibitor, Fibroblast collagenase inhibitor
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
TIMP-1_WB
Western blot analysis of recombinant human TIMP-1 protein using anti-TIMP-1, clone F31P2A5.
  • TIMP-1_WB
    Western blot analysis of recombinant human TIMP-1 protein using anti-TIMP-1, clone F31P2A5.
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635302 100 µg $229
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Description

TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD. TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes. High levels TIMP-1 protein has been found in several types of cancers including breast cancer and this increase associated with a poor patient prognosis. TIMP-1 has also been implicated in the inhibition of apoptosis, promotion of growth, and process of angiogenesis. TIMP-1 may be useful as a prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1). Clone F31P2A5 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human and monkey TIMP-1.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
Non-Human Primate
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ovalbumin-conjugated synthetic Peptide FQALGDAADIR
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested
IHC-P, ELISA - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 4 µg per 1 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Murray G et al. 1998. Gut. 43:791. (IHC)
RRID
AB_2204557 (BioLegend Cat. No. 635302)

Antigen Details

Structure
Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD.
Distribution

Extracellular, expressed in a number of connective tissues, plasma and amniotic fluid.

Function
TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes. High levels of TIMP-1 protein has been found in several types of cancers (eg. breast cancer) where the increase has been associated with a poor patient prognosis.
Interaction
MMP-1, MMP-3, MMP-9
Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology
Molecular Family
Enzymes and Regulators
Antigen References

1. Lambert E, et al. 2004. Crit. Rev. Oncol./Hematol. 49:187

Gene ID
7076 View all products for this Gene ID
UniProt
View information about TIMP-1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 09/21/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

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