- Clone
- N67/15 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TRPC5; TRP5; PPP1R159
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
601152 | 100 µg | $165 |
TrpC5 is a non-voltage dependent calcium-permeable ion channel in the superfamily of transient receptor potential channels. TrpC5 protein is abundant in the nervous and cardiovascular systems and maintains intracellular Ca2+ levels by forming homotetrameric or heterotetrameric channels with TrpC4 and/or TrpC1. Upon receiving physiological and mechanical stimuli, TrpC5 induces Ca2+ influx and cell membrane depolarization.
Product DetailsProduct Details
- Verified Reactivity
- Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial synthetic peptide of human TrpC5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone recognizes endogenous TrpC5 proteins on rat eye tissues.
- RRID
-
AB_2904440 (BioLegend Cat. No. 601152)
Antigen Details
- Structure
- TrpC5 is a 973 amino acid protein with a molecular mass of 111 kD.
- Distribution
-
Membrane/ Retina ganglion cells, endothelial cells, smooth muscle cells
- Function
- TrpC5 functions as a sensor for extracellular stimuli to regulate intracellular Ca2+ levels.
- Cell Type
- Endothelial cells, Neurons
- Biology Area
- Cell Biology, Neuroscience
- Molecular Family
- Ion Channels
- Antigen References
-
- Song K, et al. 2021. Elife. 10:e63429.
- Du SL, et al. 2021. Rev Cardiovasc Med. 22:127-135.
- Duan J, et al. 2019. Sci Adv. 5:eaaw7935.
- Gene ID
- 7224 View all products for this Gene ID
- UniProt
- View information about TrpC5 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All TrpC5 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-TrpC5 | N67/15 | IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-TrpC5
IHC staining of anti-TrpC5 antibody (clone N67/15) on formal...
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