- Clone
- A20095H (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD87, MO3, Plasminogen activator urokinase receptor, uPAR, URKR
- Isotype
- Mouse IgM, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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946203 | 100 µg | $358 | ||||
946204 | 1 mg | $1205 |
Select size of product is eligible for a 40% discount! Promotion valid until December 31, 2024. Exclusions apply. To view full promotion terms and conditions or to contact your local BioLegend representative to receive a quote, visit our webpage.
PLAUR (plasminogen activator urokinase receptor), also known as urokinase plasminogen activator-receptor (uPAR), is part of the plasminogen activation system, which is involved in tissue reorganization, cell migration, cell cycle regulation, and cell adhesion. PLAUR was originally identified as a saturable binding site for urokinase on the cell surface, and thus, restricting plasminogen activation to the immediate vicinity of the cell membrane. Due to lack of transmembrane or cytoplasmic domains, PLAUR may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its C-terminus. A soluble form of PLAUR has been identified. The membrane-bound PLAUR is expressed on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. This molecule plays a role in cell adhesion and chemotaxis through binding to β1, β2, and β3 integrins. Recently, it was found that soluble PLAUR is increased in plasma of patients with active lupus nephritis, suggesting an association with pathological features of the disease. In addition, soluble PLAUR has been linked as a causative factor and also a biomarker of several diseases including tumor metastasis, focal and segmental glomerulosclerosis, hepatocellular carcinoma, and coronary artery disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human PLAUR (uPAR)
- Formulation
- 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
- Endotoxin Level
- Less than 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by blocking the binding of 3 µg/mL biotinylated recombinant hPLAUR (uPAR) to 2 µg/mL immobilized human u-Plasminogen Activator (Urokinase) (Cat. No. 755304). ND50 range: 4 - 20 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2894531 (BioLegend Cat. No. 946203)
AB_2894531 (BioLegend Cat. No. 946204)
Antigen Details
- Structure
- Monomer
- Distribution
-
Granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes, and activated T cells
- Function
- Convert plasminogen to plasmin, cell adhesion, and chemotaxis
- Interaction
- Human PLAUR is able to bind uPA in a dose dependent manner.
- Ligand/Receptor
- uPA; LRP1 (CD91)
- Antigen References
-
1. Llinas P, et al. 2005. EMBO J. 24:1655.
2. Beaufort N, et al. 2004. J. Immunol. 172:540.
3. Tarui T, et al. 2001. J. Biol. Chem. 276:3983.
4. Qin DD, et al. 2014. Lupus 0961203314558857.
5. Thuno M, et al. 2009. Dis. Markers 27:157.
6. Alfano D, et al. 2009. Front Biosci. 14:3782.
7. Spinale JM, et al. 2014. Kidney Int. 10:1038.
8. Chounta A, et al. 2014. Liver Int. 2:601.
9. Harskamp RE and Roe MT. 2014. J. Am. Heart Assoc. 5:e001431. - Gene ID
- 5329 View all products for this Gene ID
- UniProt
- View information about PLAUR on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- Do you guarantee that your antibodies are totally pathogen free?
-
BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.
- Does BioLegend test each Ultra-LEAF™ antibody by functional assay?
-
No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.
- Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?
-
No, BioLegend does not test for pathogens in-house unless otherwise indicated. However, we can recommend an outside vendor to perform this testing as needed.
- Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?
-
We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.
Other Formats
View All PLAUR Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Ultra-LEAF™ Purified anti-human PLAUR (uPAR) Antibody | A20095H | Block |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Ultra-LEAF™ Purified anti-human PLAUR (uPAR) Antibody
Biotinylated recombinant human PLAUR (uPAR) (black circles) ...
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