Brilliant Violet 605™ anti-human CD269 (BCMA) Antibody

Pricing & Availability
Clone
19F2 (See other available formats)
Regulatory Status
RUO
Other Names
BCM, TNFRSF17
Isotype
Mouse IgG2a, κ
19F2_BV605_CD269_Antibody_041724
U266 cells (a myeloma cell line) were stained with anti-human CD269 (BCMA) (clone 19F2) Brilliant Violet 605™ (filled histogram) or mouse IgG2a, κ Brilliant Violet 605™ isotype control (open histogram).
  • 19F2_BV605_CD269_Antibody_041724
    U266 cells (a myeloma cell line) were stained with anti-human CD269 (BCMA) (clone 19F2) Brilliant Violet 605™ (filled histogram) or mouse IgG2a, κ Brilliant Violet 605™ isotype control (open histogram).
Compare all formats See Brilliant Violet 605™ spectral data
Cat # Size Price Quantity Check Availability
357537 25 tests $221.00
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357538 100 tests $435.00
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Description

CD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single pass transmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a B cell maturation factor, essential for the long-term survival of plasma cells. It is expressed by plasmablasts, plasma cells, and germinal center B cells. The ligands of CD269 are BAFF and APRIL, and its cytoplasmic domain binds several of the TRAF family members.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BCMA-mouse IgG Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605™ under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 605™ excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605™ is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
RRID
AB_3106165 (BioLegend Cat. No. 357537)
AB_3106165 (BioLegend Cat. No. 357538)

Antigen Details

Structure
Single pass transmembrane protein, member of the TNFR superfamily, 1 TNFR-Cys domain, 27 kD
Distribution

Plasmablasts, plasma cells, germinal center B cells

Function
B cell maturation factor, essential for survival of plasma cells
Interaction
Associates with several TRAF family members
Ligand/Receptor
BAFF, APRIL
Cell Type
B cells, Plasma cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Coquery CM and Erickson LD. 2012. Crit. Rev. Immunol. 32:287. 
2. Notas G, et al. 2012. J. Immunol. 189:4748. 
3. Rickert RC, et al. 2011. Immunol. Rev. 244:115. 
4. Mesin L, et al. 2011. J. Immunol. 187:2867.

Gene ID
608 View all products for this Gene ID
UniProt
View information about CD269 on UniProt.org
Go To Top Version: 1    Revision Date: 04/17/2024

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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