- Clone
- 8F10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TACI
- Isotype
- Rat IgG2a, κ
-
C57BL/6 splenocytes stained with 8F10 PE and RA3-6B2 APC
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 133403 | 50 µg | $98.00 | |||
| 133404 | 200 µg | $275.00 | |||
Transmembrane Activator and CAML Interactor (TACI) is a tumor necrosis factor receptor superfamily (TNFSF) member. It is a type III transmembrane protein sharing a high degree of homology with B cell maturation antigen (BCMA) among TNFSF members. It binds to the ligands BAFF (BLyS) and APRIL. CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity as well. The actual role for TACI in the mouse has still not been fully determined.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Rat RBL transfected cell line
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Siegel RM, et al. 2001. Nat. Immunol. 2:577.
- Von Bulow GU, et al. 1997. Science 278:138.
- Yan M, et al. 2001. Nat. Immunol. 2:638.
- Diaz-de-Durana Y, et al. 2006. Blood 107:594.
- Moir S, et al. 2012. Blood. 120:4850. PubMed.
- Product Citations
-
- RRID
-
AB_2203542 (BioLegend Cat. No. 133403)
AB_2203542 (BioLegend Cat. No. 133404)
Antigen Details
- Structure
- TACI/CD267 is a type III transmembrane protein belonging to TNF receptor superfamily (TNFSF). Among TNFSF members, TACI shares a high degree of homology with B cell maturation antigen (BCMA). It binds to the ligands BAFF (BLyS) and APRIL.
- Distribution
-
CD267 is expressed predominantly by splenic transitional type 2 and marginal zone B cells, as well as activated B cells. But it is notably absent from germinal center B cells.
- Function
- CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity.
- Ligand/Receptor
- BAFF (Blys/TALL-1/THANK) and APRIL
- Cell Type
- B cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Ng LG, et al. 2004. J. Immunology. 173:807.
- Gene ID
- 57916 View all products for this Gene ID
- UniProt
- View information about CD267 on UniProt.org
Other Formats
View All CD267 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse CD267 (TACI) | 8F10 | FC |
| TotalSeq™-C1266 anti-mouse CD267 (TACI) | 8F10 | PG |
| TotalSeq™-B1266 anti-mouse CD267 (TACI) | 8F10 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-mouse CD267 (TACI)
C57BL/6 splenocytes stained with 8F10 PE and RA3-6B2 APC -
TotalSeq™-C1266 anti-mouse CD267 (TACI)
-
TotalSeq™-B1266 anti-mouse CD267 (TACI)