- Clone
- 10D1-J16 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3
- Isotype
- Mouse IgG2a, κ
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CXCR7-transfected L1.2 cells were stained with purified CXCR7 (clone 10D1-J16) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 391402 | 100 µg | $265.00 | |||
CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2565219 (BioLegend Cat. No. 391402)
Antigen Details
- Structure
- G Protein-Coupled Receptor super family
- Distribution
-
Monocytes, B cells, T cells, and mature dendritic cells.
- Function
- Regulates trafficking and activation of leukocytes.
- Ligand/Receptor
- CXCL12/SDF-1 and CXCL11/I-TAC.
- Cell Type
- B cells, Dendritic cells, Monocytes, T cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Torossian F, et al. 2014. Blood 123:191.
2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629.
3. Yates TJ, et al. 2013. Cancer 119:61.
4. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
5. Infantino S, et al. 2006. J. Immunol. 176:2197. - Gene ID
- 57007 View all products for this Gene ID
- UniProt
- View information about CXCR7 on UniProt.org
Other Formats
View All CXCR7 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CXCR7 | 10D1-J16 | FC |
| PE anti-human CXCR7 | 10D1-J16 | FC |
| APC anti-human CXCR7 | 10D1-J16 | FC |
| TotalSeq™-B1294 anti-human CXCR7 | 10D1-J16 | PG |
| TotalSeq™-C1294 anti-human CXCR7 | 10D1-J16 | PG |
| TotalSeq™-A1294 anti-human CXCR7 | 10D1-J16 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CXCR7
CXCR7-transfected L1.2 cells were stained with purified CXCR... -
PE anti-human CXCR7
CXCR7 transfected L1.2 cells were stained with CXCR7 (clone ... -
APC anti-human CXCR7
CXCR7 transfected L1.2 cells were stained with CXCR7 (clone ... -
TotalSeq™-B1294 anti-human CXCR7
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TotalSeq™-C1294 anti-human CXCR7
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TotalSeq™-A1294 anti-human CXCR7