- Clone
- W17239A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Peptidylprolyl Isomerase F, Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial, Mitochondrial Cyclophilin, Cyclophilin F, Rotamase F, PPIase F, CyP-M, CYP3, CypD, Cyclophilin 3, Cyp-D, CyP-D, PPIF
- Isotype
- Rat IgG2a, λ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
670001 | 25 µg | 81€ | ||||
670002 | 100 µg | 203€ |
Cyclophilin D is one of the three components of the permeability transition pore (PTP) localized in the mitochondrial matrix. The opening of the PTP is a key event in the initiation of cell death which leads to mitochondrial swelling, outer membrane rupture, and the release of apoptotic regulators such as cytochrome C. Cyclophilin D promotes mitochondrial permeability transition (mPT) in response to increased Ca2+ level. Cyclophilin D deficient mice have shown desensitization to mTP and require twice as much Ca2+ intake for the opening of the PTP compared to wild-type mice.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Partial recombinant human PPIF protein (30-207 a.a.)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone recognizes human cyclophilin D
This clone failed IP testing - Product Citations
-
- RRID
-
AB_2814520 (BioLegend Cat. No. 670001)
AB_2814520 (BioLegend Cat. No. 670002)
Antigen Details
- Structure
- Cyclophilin D is a 207 amino acid protein with a predicted molecular weight of 22 kD
- Distribution
-
Mitochondrial matrix/Ubiquitously expressed
- Function
- Apoptotic regulator
- Biology Area
- Cell Death, Mitochondrial Function
- Molecular Family
- Mitochondrial Markers
- Antigen References
-
- Baines C, et al. 2005. Nature. 434:658
- Schinzel A, et al. 2005. PNAS. 102:12005
- Basso E, et al. 2005. J BioL Chem. 280:18558
- Gene ID
- 10105 View all products for this Gene ID
- UniProt
- View information about Cyclophilin D on UniProt.org
Related FAQs
Other Formats
View All Cyclophilin D Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Cyclophilin D | W17239A | WB,ICC |
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