APC anti-human CD8 Antibody anti-CD8a

Pricing & Availability

Analyte Specific Reagent. Analytical and performance characteristics are not established.

Clone: SK1
Other Names: T8, Leu2
Isotype: Mouse IgG1, κ

SK1_APC_CD8_ASR_070524 — Typical results from human peripheral blood lymphocytes stained either with SK1 APC used at 5 µL/test (filled histogram) or with an isotype control (open histogram).

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980904

500 µL

363 CHF

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Description

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Product Details

Technical Data Sheet (pdf)

Product Details

Reactivity: Human
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration: 25 µg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: Suggested for Flow Cytometry

Antigen Details

Antigen References: 1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego.

Documentation

Certificate of Analysis

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Go To Top Version: 6 Revision Date: 07.31.2024

Analyte Specific Reagent. Analytical and performance characteristics are not established.

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