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APC/Fire™ 750 anti-human KLRG1 (MAFA) Antibody

Pricing & Availability
Clone
SA231A2 (See other available formats)
Regulatory Status
RUO
Other Names
CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
SA231A2_APCFire750_KLRG1_Antibody_1_070717
Human peripheral blood lymphocytes were stained with CD56 PE and KLRG1 (clone SA231A2) APC/Fire™ 750 (top) or mouse IgG2a, κ APC/Fire™ 750 isotype control (bottom).
  • SA231A2_APCFire750_KLRG1_Antibody_1_070717
    Human peripheral blood lymphocytes were stained with CD56 PE and KLRG1 (clone SA231A2) APC/Fire™ 750 (top) or mouse IgG2a, κ APC/Fire™ 750 isotype control (bottom).
  • SA231A2_APCFire750_KLRG1_Antibody_2_070717
Compare all formats See APC/Fire™ 750 spectral data
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367717 25 tests 176 CHF
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367718 100 tests 405 CHF
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Description

Killer cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). KLRG1 is expressed by subsets of NK, effector and memory T cells. KLRG1 inhibits cell activation and proliferation, and is a marker of T cell senescence. Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human KLRG1-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood.

* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Szabo PA, et al. 2021. Immunity. 54(4):797-814.e6. PubMed
RRID
AB_2687391 (BioLegend Cat. No. 367717)
AB_2687391 (BioLegend Cat. No. 367718)

Antigen Details

Structure
Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.
Distribution

Subsets of NK, effector and memory T cells.

Function
Inhibits cell activation and proliferation, marker of T cell senescence.
Interaction
AKT
Ligand/Receptor
E-, N-, and R- cadherins
Cell Type
NK cells, T cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Shi L, et al. 2014. J. Immunol. 192:649.

Gene ID
10219 View all products for this Gene ID
UniProt
View information about KLRG1 on UniProt.org
Go To Top Version: 0    Revision Date: 07.07.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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