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PE anti-human CD108 Antibody

Pricing & Availability
Clone
KS-2 (See other available formats)
Regulatory Status
RUO
Other Names
CD108, Semaphorin 7A
Isotype
Mouse IgG2a, κ
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Product Citations
publications
KS2_PE_CD108_Antibody_091622
PHA stimulated (3 days) human peripheral blood lymphocytes were stained with anti-human CD108 (clone KS-2) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
  • KS2_PE_CD108_Antibody_091622
    PHA stimulated (3 days) human peripheral blood lymphocytes were stained with anti-human CD108 (clone KS-2) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
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376603 25 tests 171 CHF
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376604 100 tests 258 CHF
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Description

CD108 is an 80 kD GPI-linked membrane-bound semaphorin, also known as the John-Milton-Hagen (JMH) blood group antigen, semaphorin 7A, H-SEMA, and SEMAL. It contains an Ig-like domain and is expressed at low levels on erythrocytes and lymphocytes. The expression of CD108 on lymphocytes is upregulated upon activation, and it plays an important role in modulating inflammation and T-cell-mediated immune responses. CD108 is a guidance protein that is involved in central and peripheral axon growth. The interaction of CD108 with its receptor PlexinC1 induces activation of monocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
PHA-activated PBMC
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. New York.
  2. Angelisova P, et al. 1999. Immunobiology 200:234-45.
RRID
AB_2927888 (BioLegend Cat. No. 376603)
AB_2927888 (BioLegend Cat. No. 376604)

Antigen Details

Structure
Membrane-bound semaphorin with GPI linkage and contains and IgG like domain, approximately 80kD
Distribution

Widely expressed in spleen, thymus, testis, ovary, heart, lung, kidney, brain, small intestine, red cells, monocytes, and T cells

Function
Modulates inflammation and T-cell-mediated immune responses. Guidance protein involved in central and peripheral axon growth. Interaction with PlexinC1 induces activation of monocytes.
Ligand/Receptor
PlexinC1
Cell Type
Erythrocytes, Monocytes, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Mine, T, et al. 2000. Tissue Antigens. 55: 429–36.
  2. Jeroen Pasterkamp, et al. 2003. Nature. 424:398-405.
  3. Seltsam A, et al. 2007. Transfusion. 47:133-46.
  4. Suzuki K, et al. 2007. Nature. 446:680-4.
Gene ID
8482 View all products for this Gene ID
UniProt
View information about CD108 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 09.16.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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