Purified anti-human CD108 Antibody, CD108, KS-2

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Clone: KS-2 (See other available formats)
Regulatory Status: RUO
Other Names: CD108, Semaphorin 7A
Isotype: Mouse IgG2a, κ
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Product Citations: publications

KS2_PURE_CD108_Antibody_030322 — PHA stimulated (3 days) human peripheral blood lymphocytes were stained with purified anti-human CD108 (clone KS-2) (filled histogram) or mouse IgG2a, κ isotype control (open histogram) followed by PE anti-mouse IgG2a.

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376602

100 µg

317 CHF

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Description

CD108 is an 80 kD GPI-linked membrane-bound semaphorin, also known as the John-Milton-Hagen (JMH) blood group antigen, semaphorin 7A, H-SEMA, and SEMAL. It contains an Ig-like domain and is expressed at low levels on erythrocytes and lymphocytes. The expression of CD108 on lymphocytes is upregulated upon activation, and it plays an important role in modulating inflammation and T-cell-mediated immune responses. CD108 is a guidance protein that is involved in central and peripheral axon growth. The interaction of CD108 with its receptor PlexinC1 induces activation of monocytes.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: PHA-activated PBMC
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2910429 (BioLegend Cat. No. 376602)

Antigen Details

Structure: Membrane-bound semaphorin with GPI linkage and contains and IgG like domain, approximately 80kD
Distribution: Widely expressed in spleen, thymus, testis, ovary, heart, lung, kidney, brain, small intestine, red cells, monocytes, and T cells
Function: Modulates inflammation and T-cell-mediated immune responses. Guidance protein involved in central and peripheral axon growth. Interaction with PlexinC1 induces activation of monocytes.
Ligand/Receptor: PlexinC1
Cell Type: Erythrocytes, Monocytes, T cells
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: Mine, T, et al. 2000. Tissue Antigens. 55: 429–36.

Jeroen Pasterkamp, et al. 2003. Nature. 424:398-405.

Seltsam A, et al. 2007. Transfusion. 47:133-46.

Suzuki K, et al. 2007. Nature. 446:680-4.
Gene ID: 8482 View all products for this Gene ID
UniProt: View information about CD108 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD108 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD108	KS-2	FC
PE anti-human CD108	KS-2	FC
FITC anti-human CD108	KS-2	FC
APC anti-human CD108	KS-2	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 03.03.2022

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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