- Clone
- A94B10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TLR7, Toll-like receptor 7, CD287
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
160003 | 25 µg | 146 CHF | ||||
160004 | 100 µg | 365 CHF |
Toll-like receptor (TLR) 7, also known as CD287 is a type 1 transmembrane protein, member of the TLR receptor family. TLR7 is expressed intracellularly in plasmacytoid dendritic cells, myeloid cells, and B lymphocytes and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR7 signals through MyD88, which leads to the activation and secretion of IFN-α/β and other inflammatory cytokines.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Ba/F3 cells expressing flag-6xHis-conjugated mouse TLR7
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Kanno A, et al. 2013. Int Immunol. 25:413
- RRID
-
AB_2876562 (BioLegend Cat. No. 160003)
AB_2876562 (BioLegend Cat. No. 160004)
Antigen Details
- Structure
- Type 1 transmembrane protein, member of the Toll-like receptor (TLR) family
- Distribution
-
Myeloid and plasmacytoid dendritic cells, and B lymphocytes
- Function
- Pattern recognition receptor that detects single-stranded RNA, induces proinflammatory cytokine production
- Ligand/Receptor
- Single-stranded RNA
- Cell Type
- B cells, Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Innate Immune Signaling
- Antigen References
-
- Majer O, et al. 2019. Nature. 575:371.
- Akilesh HM, et al. 2019. Science 363(6423)
- Hemmi H, et al. 2002. Nat. Immunol. 3:196.
- Gene ID
- 170743 View all products for this Gene ID
- UniProt
- View information about CD287 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD287 (TLR7) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-mouse CD287 (TLR7) | A94B10 | ICFC,FC |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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-
PE anti-mouse CD287 (TLR7)
C57BL/6 splenocytes were stained with CD45R/B220 APC and CD3...
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