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PE anti-mouse/human CD207 (Langerin) Antibody

Pricing & Availability
Clone
4C7 (See other available formats)
Regulatory Status
RUO
Other Names
CLEC4K
Isotype
Mouse IgG2a, κ
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Product Citations
publications
4C7_PE_1_080612
Cells from a collagenase-digested Balb/c mouse spleen were stained with CD11c Brilliant Violet 605™ and CD207 (Langerin, clone 4C7) PE (top) or mouse IgG2a, κ PE isotype control (bottom). Data shown was gated on the CD3- B220- population.
  • 4C7_PE_1_080612
    Cells from a collagenase-digested Balb/c mouse spleen were stained with CD11c Brilliant Violet 605™ and CD207 (Langerin, clone 4C7) PE (top) or mouse IgG2a, κ PE isotype control (bottom). Data shown was gated on the CD3- B220- population.
  • 4C7_PE_2_080612
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144203 25 µg 117 CHF
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144204 100 µg 335 CHF
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Description

CD207, also known as langerin, is a 40 kD single-pass type II transmembrane protein, member of the C-type lectin family. CD207 is expressed on the cell surface and Birbeck granules (BGs) of Langerhans cells, and subsets of thymic and splenic dendritic cells. Its ligands are mannose, n-acetylglucosamine, fucose, and sulfated glycans. Langerin is involved in the antigen processing pathway through capture and internalization of its ligands.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human
Reported Reactivity
Cynomolgus, Rabbit, Pig
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Langerin extracellular domain-Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Zhou H, et al. 2022. EMBO Rep. 23:e53791. PubMed
  2. Hardman CS, et al. 2022. Nat Commun. 13:7535. PubMed
  3. Tatsumi N, et al. 2022. STAR Protoc. 3:101845. PubMed
  4. Huang T, et al. 2023. Cell Death Dis. 14:354. PubMed
  5. Li Z, et al. 2021. Immunology. 163:105. PubMed
  6. Wong Fok Lung T, et al. 2020. Nat Microbiol. 141:5. PubMed
  7. Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed
  8. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  9. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  10. Acker KP, et al. 2019. iScience. 19:281. PubMed
  11. Zhang X, et al. 2022. JCI Insight. 7:. PubMed
  12. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  13. Sheng J, et al. 2021. eLife. 10:00. PubMed
  14. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  15. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
RRID
AB_2561498 (BioLegend Cat. No. 144203)
AB_2561498 (BioLegend Cat. No. 144204)

Antigen Details

Structure
Single-pass type II transmembrane protein, 40 kD, one C-type lectin domain, homotrimer
Distribution

Langerhans cells, subsets of thymic and splenic dendritic cells

Function
Antigen uptake, antigen processing
Ligand/Receptor
Mannose, n-acetylglucosamine, fucose, sulfated glycans
Cell Type
Dendritic cells, Langerhans cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Romani N, et al. 2012. Curr. Top. Microbiol. Immunol. 351:113.
2. Kaplan DH. 2010. Trends Immunol. 31:446.
3. Clausen BE and Kel JM. 2010. Immunol. Cell. Biol. 88:351.
4. Merad M, et al. 2008. Nat. Rev. Immunol. 8:935.

Gene ID
246278 View all products for this Gene ID 50489 View all products for this Gene ID
UniProt
View information about CD207 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 5    Revision Date: 12.08.2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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