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- Clone
- S19013C (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Unc-93 homolog B1, TLR signaling regulator
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 splenocytes were surface stained with CD11b Alexa Fluor® 647 and then treated with True-Nuclear™ Transcription Factor Buffer Set. Cells were then stained with UNC93B1 (clone S19013C) PE (left) or rat IgG2a, κ PE isotype control (right).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 162803 | 25 µg | 202 CHF | ||||
| 162804 | 100 µg | 481 CHF | ||||
Unc93b1 is a 12 pass transmembrane protein highly conserved in the endoplasmic reticulum (ER). Unc93b1 plays a role in the transport of TLRs from the ER to the cell surface or endosomes where they can engage pathogens nucleotides and trigger signaling cascades. Mutations in the Unc93b1 gene have shown to cause susceptibility to some common infections (HSV hypersensitivity in humans, and mouse cytomegalovirus).
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse UNC93B1-transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.03 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
-
AB_2888874 (BioLegend Cat. No. 162803)
AB_2888874 (BioLegend Cat. No. 162804)
Antigen Details
- Structure
- 12 pass transmembrane protein
- Antigen References
-
1. Majer. et al. 2019. Nature. 575, 371–374
2. Pelka et al. 2018. Immunity. 48, 911–922
3. Huh et al. 2014. PNAS. 111, 7072–7077 - Gene ID
- 81622 View all products for this Gene ID
- UniProt
- View information about UNC93B1 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All UNC93B1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse UNC93B1 Antibody | S19013C | ICFC |
| PE anti-mouse UNC93B1 Antibody | S19013C | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse UNC93B1 Antibody
C57BL/6 splenocytes were surface stained with CD11b Alexa Fl... -
PE anti-mouse UNC93B1 Antibody
C57BL/6 splenocytes were surface stained with CD11b Alexa Fl...
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