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Purified anti-mouse UNC93B1 Antibody

Pricing & Availability
Clone
S19013C (See other available formats)
Regulatory Status
RUO
Other Names
Unc-93 homolog B1, TLR signaling regulator
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
S19013C_PURE_UNC93B1_Antibody_1_112320
C57BL/6 splenocytes were surface stained with CD11b Alexa Fluor® 647 and then treated with True-Nuclear™ Transcription Factor Buffer Set. Cells were then stained with UNC93B1 (clone S19013C) purified (left) or rat IgG2a, κ purified isotype control (right), followed by anti-rat IgG PE.
  • S19013C_PURE_UNC93B1_Antibody_1_112320
    C57BL/6 splenocytes were surface stained with CD11b Alexa Fluor® 647 and then treated with True-Nuclear™ Transcription Factor Buffer Set. Cells were then stained with UNC93B1 (clone S19013C) purified (left) or rat IgG2a, κ purified isotype control (right), followed by anti-rat IgG PE.
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162802 100 µg 347 CHF
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Description

Unc93b1 is a 12 pass transmembrane protein highly conserved in the endoplasmic reticulum (ER). Unc93b1 plays a role in the transport of TLRs from the ER to the cell surface or endosomes where they can engage pathogens nucleotides and trigger signaling cascades. Mutations in the Unc93b1 gene have shown to cause susceptibility to some common infections (HSV hypersensitivity in humans, and mouse cytomegalovirus). 

 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse UNC93B1-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

RRID
AB_2888873 (BioLegend Cat. No. 162802)

Antigen Details

Structure
12 pass transmembrane protein
Antigen References

1. Majer. et al. 2019. Nature. 575, 371–374
2. Pelka et al. 2018. Immunity. 48, 911–922
3. Huh et al. 2014. PNAS. 111, 7072–7077

Gene ID
81622 View all products for this Gene ID
UniProt
View information about UNC93B1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.23.2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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