- Clone
- QA17A24 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Integrin αIEL chain, Integrin αE chain, αE integrin, ITGAE
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
156909 | 25 µg | 141 CHF | ||||
156910 | 100 µg | 347 CHF |
CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Mouse intestinal intraepithelial lymphocytes
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm. - Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
-
AB_2876531 (BioLegend Cat. No. 156909)
AB_2876531 (BioLegend Cat. No. 156910)
Antigen Details
- Structure
- Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
- Function
- Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
- Interaction
- T cells, Dendritic cells, Lymphocytes, Tregs
- Ligand/Receptor
- E-Cadherin
- Cell Type
- Dendritic cells, Lymphocytes, T cells, Tregs
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
- Kilshaw PJ and Murant SJ. 1990. Eur. J. Immunol. 20:2201.
- Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
- LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
- Sung SS, et al. 2006. J. Immunol. 176:2161.
- Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
- Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.
- Gene ID
- 16407 View all products for this Gene ID
- UniProt
- View information about CD103 on UniProt.org
Related FAQs
Other Formats
View All CD103 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PE anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PE/Cyanine7 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
FITC anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PE/Dazzle™ 594 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PerCP/Cyanine5.5 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
APC anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
Brilliant Violet 421™ anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PE/Fire™ 640 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PE/Fire™ 810 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PerCP/Fire™ 780 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PE/Fire™ 700 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
PerCP/Fire™ 806 anti-mouse CD103 Recombinant Antibody | QA17A24 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD103 Recombinant Antibody
C57BL/6 Splenocytes were stained with purified anti-mouse CD... -
PE anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 FITC an... -
PE/Cyanine7 anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 Brillia... -
FITC anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 Brillia... -
PE/Dazzle™ 594 anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 FITC an... -
PerCP/Cyanine5.5 anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 FITC an... -
APC anti-mouse CD103 Recombinant Antibody
C57BL/6 mouse splenocytes were stained with CD3 PE and anti-... -
Brilliant Violet 421™ anti-mouse CD103 Recombinant Antibody
C57BL/6 mouse splenocytes were stained with CD3 PE and anti-... -
PE/Fire™ 640 anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 APC and... -
PE/Fire™ 810 anti-mouse CD103 Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse CD3 Alexa F... -
PerCP/Fire™ 780 anti-mouse CD103 Recombinant Antibody
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 ... -
PE/Fire™ 700 anti-mouse CD103 Recombinant Antibody
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 B... -
PerCP/Fire™ 806 anti-mouse CD103 Recombinant Antibody
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 F...
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