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Purified anti-α-1-Fetoprotein Antibody

Pricing & Availability
Clone
BSB-23 (See other available formats)
Regulatory Status
RUO
Other Names
Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP, AFP
Isotype
Mouse IgG2a, κ
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Product Citations
publications
BSBdash23_PURE_alpha1Fetoprotein_Antibody_IHCP_082416
IHC staining of anti-α-1-Fetoprotein antibody (clone BSB-23) on formalin-fixed paraffin-embedded human fetal liver tissue. Following antigen retrieval using sodium citrate, the tissue was incubated with the primary antibody for 30 minutes at room temperature at 1 µg/mL. BioLegend's Ultra Streptavidin (USA) HRP Detection Kit was used for detection, followed by counterstaining with hematoxylin.
  • BSBdash23_PURE_alpha1Fetoprotein_Antibody_IHCP_082416
    IHC staining of anti-α-1-Fetoprotein antibody (clone BSB-23) on formalin-fixed paraffin-embedded human fetal liver tissue. Following antigen retrieval using sodium citrate, the tissue was incubated with the primary antibody for 30 minutes at room temperature at 1 µg/mL. BioLegend's Ultra Streptavidin (USA) HRP Detection Kit was used for detection, followed by counterstaining with hematoxylin.
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847102 100 µg 347 CHF
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Description

α-1-Fetoprotein (AFP) is a major plasma protein produced by the yolk sac and the liver during fetal life. AFP is thought to be the fetal counterpart of serum albumin. Since only traces of AFP are found in adult serum, elevated levels suggest either a benign or malignant lesion of the liver, a Yolk-Sac Carcinoma, or one of a few other tumors.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Dog
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Cyclic peptide corresponding to amino acids 199-161 of human α-1-Fetoprotein.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

IHC-P - Quality tested
IHC-F, WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.1 - 1.0 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2629665 (BioLegend Cat. No. 847102)

Antigen Details

Structure
AFP is a 609 amino acid protein with a molecular mass of 69 kD.
Distribution

Tissue distribution: fetal liver and yolk sac.
Cellular distribution: extracellular, secreted, and cytosol.

Function
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
Biology Area
Cancer Biomarkers, Cell Biology, Neuroscience
Antigen References

1. Jacobsen GK, et al. 1981. Am. J. Surg. Pathol. 5:257. PubMed
2. Peyrol S, et al. 1978. Digestion 18:351. PubMed
3. Tsung SH. 1977. Arch. Pathol. Lab. Med. 101:572. PubMed
4. Goodman ZD, et al. 1985. Cancer 55:124. PubMed
5. Roth LM, et al. 1976. Cancer 37:812. PubMed

Gene ID
174 View all products for this Gene ID
UniProt
View information about alpha-1-Fetoprotein on UniProt.org
Go To Top Version: 2    Revision Date: 09.20.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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