Purified anti-human CD49a Antibody anti-CD49a

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Clone: TS2/7 (See other available formats)
Regulatory Status: RUO
Other Names: α1 integrin, VLA-1 α chain, Integrin α1 chain, ITGA1
Isotype: Mouse IgG1, κ
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Product Citations: publications

Human cervical cancer cell line, Hela, stained with purified TS2/7, followed by anti-mouse IgG FITC

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328302

100 µg

112 CHF

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Description

CD49a is a 200 kD type I transmembrane glycoprotein also known as α₁ integrin, VLA-1 α chain, or Integrin α₁. It associates with CD29 (β₁ integrin) to form VLA-1 complex, a collagen IV and alminin-1 receptor. It is expressed on activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Reported Reactivity: African Green, Baboon, Cynomolgus, Rhesus
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human CTL line
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported applications include: immunoprecipitation¹, immunohistochemical staining¹ of acetone-fixed frozen tissue sections, and spatial biology (IBEX)^3,4.
RRID: AB_1236385 (BioLegend Cat. No. 328302)

Antigen Details

Structure: Integrin alpha chain family, Type I membrane protein, alpha chain of heterodimeric integrin receptor, 200 kD. Associates with CD29 to form VLA-1 complex
Distribution: Activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells
Function: Adhesion, leukocyte migration
Ligand/Receptor: With integrin β₁ (CD29) forms receptor for laminin-1 and collagen IV
Cell Type: Fibroblasts, Mesenchymal cells, Mesenchymal Stem Cells, Monocytes, NK cells, T cells
Biology Area: Immunology, Stem Cells
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiley-Liss Press. p122

Boiret N, et al. 2005. Exp. Hematol. 33:219
Gene ID: 3672 View all products for this Gene ID
UniProt: View information about CD49a on UniProt.org

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Other Formats

View All CD49a Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD49a	TS2/7	FC
FITC anti-human CD49a	TS2/7	FC
PE anti-human CD49a	TS2/7	FC,SB
Alexa Fluor® 647 anti-human CD49a	TS2/7	FC,SB
PE/Cyanine7 anti-human CD49a	TS2/7	FC
APC anti-human CD49a	TS2/7	FC
TotalSeq™-A0575 anti-human CD49a	TS2/7	PG
APC/Fire™ 750 anti-human CD49a	TS2/7	FC
TotalSeq™-C0575 anti-human CD49a	TS2/7	PG
PerCP/Cyanine5.5 anti-human CD49a	TS2/7	FC
TotalSeq™-B0575 anti-human CD49a Antibody	TS2/7	PG

Certificate of Analysis

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Go To Top Version: 2 Revision Date: 08.31.2022

For Research Use Only. Not for diagnostic or therapeutic use.

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