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Purified anti-mouse CD11a Antibody

Pricing & Availability
Clone
I21/7 (See other available formats)
Regulatory Status
RUO
Other Names
αL integrin, LFA-1 α subunit, Ly-15, Ly-21, ITGAL,
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
I21slash7_PURE_CD11a_Antibody_030117
C57BL/6 mouse splenocytes were stained with purified CD11a (clone I21/7) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram) followed by PE Goat anti-rat IgG.
  • I21slash7_PURE_CD11a_Antibody_030117
    C57BL/6 mouse splenocytes were stained with purified CD11a (clone I21/7) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram) followed by PE Goat anti-rat IgG.
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153102 500 µg 223 CHF
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Description

CD11a is a 180 kD glycoprotein, also known as αL integrin, LFA-1 α, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Whole T cells Lymphoma BW5147 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Trowbridge IS, et al. 1981. J. Exp. Med. 154:1517.
  2. Champe M, et al. 1995. J. Biochem. 270:1388.
Product Citations
  1. McClellan BL, et al. 2022. STAR Protoc. 3:101357. PubMed
RRID
AB_2650943 (BioLegend Cat. No. 153102)

Antigen Details

Structure
Integrin, associated with integrin CD18, 180 kD
Distribution

Lymphocytes, granulocytes, monocytes, macrophages

Function
Intercellular adhesion
Interaction
Associates with CD18
Ligand/Receptor
ICAM-1 (CD54), ICAM-2(CD102), ICAM-3(CD50)
Cell Type
Granulocytes, Lymphocytes, Macrophages, Monocytes, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Signal Transduction
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lub M, et al. 1995. Immunol. Today 16:479.

Gene ID
16408 View all products for this Gene ID
UniProt
View information about CD11a on UniProt.org
Go To Top Version: 0    Revision Date: 03.13.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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