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Purified anti-mouse CD182 (CXCR2) Antibody

Pricing & Availability
Clone
SA044G4 (See other available formats)
Regulatory Status
RUO
Other Names
IL-8RB, GRO/MGSA, Cmkar2
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
SA044G4_Purified_CD182_Antibody_FC_1_031615
C57BL/6 mouse bone marrow cells were stained with purified CXCR2 (clone SA044G4, top) or purified rat IgG2a, κ isotype control (bottom), followed by anti-rat IgG PE and posteriorly, costained with Ly-6G/Ly-6C APC.
  • SA044G4_Purified_CD182_Antibody_FC_1_031615
    C57BL/6 mouse bone marrow cells were stained with purified CXCR2 (clone SA044G4, top) or purified rat IgG2a, κ isotype control (bottom), followed by anti-rat IgG PE and posteriorly, costained with Ly-6G/Ly-6C APC.
  • SA044G4_Purified_CD182_Antibody_FC_2_031615
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149302 100 µg 265 CHF
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Description

CD182, also known as CXCR2, is a G-protein coupled receptor with 7 transmembrane regions that is involved in chemotaxis, neutrophil activation and angiogenesis. CXCR2 is expressed by neutrophils, basophils, subset of T cells, monocytes, macrophages, NK and NKT cells. Its ligands are CXCL1, CXCL2, CXCL3 and CXCL5.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CXCR2-transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  2. Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed
  3. Noh JR, et al. 2018. Sci Rep. 8:15222. PubMed
  4. Wang Y, et al. 2021. Cancer Cell. 39:1375. PubMed
  5. McClellan BL, et al. 2022. STAR Protoc. 3:101357. PubMed
  6. Zhu YP et al. 2018. Cell reports. 24(9):2329-2341 . PubMed
RRID
AB_2565277 (BioLegend Cat. No. 149302)

Antigen Details

Structure
G-protein coupled receptor, 7 transmembrane regions.
Distribution

Neutrophils, basophils, subset of T cells, monocytes, macrophages, and natural killer cells (NK).

Function
Chemotaxis, neutrophil activation, and angiogenesis
Ligand/Receptor
CXCL1, CXCL2, CXCL3, and CXCL5.
Cell Type
Neutrophils
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Spaan AN, et al. 2014. Nat. Commun. 5:5438.
2. Natsuaki Y, et al. 2014. Nat. Immunol. 11:1064.
3. Hsieh CY, et al. 2014. J. Immunol. 193:3693.
4. Diana J, and Lehuen A. 2014. EMBO Mol. Med. 6:1090.
5. Stoolman JS, et al. 2014. J. Immunol. 193:564.

Gene ID
12765 View all products for this Gene ID
UniProt
View information about CD182 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03.16.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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