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Purified anti-mouse CD192 (CCR2) Recombinant Antibody

Pricing & Availability
Clone
QA18A56 (See other available formats)
Regulatory Status
RUO
Other Names
C-C motif chemokine receptor 2, CD192
Isotype
Rat IgG2b, κ
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Product Citations
publications
QA18A56_PURE_CD192_CCR2_Antibody_RECOM_091120.png
C57BL/6 bone marrow was stained with Ly-6G PE/Cyanine7, CD11b Brilliant Violet 785™, and purified CD192 (CCR2) recombinant (clone QA18A56) (left) or rat IgG2b, κ isotype control (right) followed by anti-rat IgG PE. Dot plots are gated on Ly-6G negative cells.
  • QA18A56_PURE_CD192_CCR2_Antibody_RECOM_091120.png
    C57BL/6 bone marrow was stained with Ly-6G PE/Cyanine7, CD11b Brilliant Violet 785™, and purified CD192 (CCR2) recombinant (clone QA18A56) (left) or rat IgG2b, κ isotype control (right) followed by anti-rat IgG PE. Dot plots are gated on Ly-6G negative cells.
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160102 500 µg 581 CHF
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Description

CD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone binds to CD192, also known as CCR2, in mouse.

This recombinant antibody clone is derived from clone SA203G11.

RRID
AB_2876563 (BioLegend Cat. No. 160102)

Antigen Details

Structure
G-protein-coupled receptor, 7-transmembrane protein, 42 kD.
Distribution

Monocytes/macrophages and basophils

Function
Mediator of monocyte chemotaxis and bone marrow homeostasis
Ligand/Receptor
MCP-1, Ccl2, Ccl7, and Ccl13
Cell Type
Basophils, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Mack M, et al. 2001. J. Immunol. 166:4697.
2. Dutta P, et al. 2015. Cell Stem Cell. 16:477.
3. Li L, et al. 2008. Kidney Int. 74:1526.

Gene ID
12772 View all products for this Gene ID
UniProt
View information about CD192 on UniProt.org
Go To Top Version: 2    Revision Date: 03.26.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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