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APC anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
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Product Citations
publications
M1slash70_APC_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram) (gated on total cells).
  • M1slash70_APC_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram) (gated on total cells).
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
101211 25 µg 27€
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101212 100 µg 84€
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Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  2. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  3. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  4. Li F, et al. 2022. Mediators Inflamm. 2022:5782922. PubMed
  5. Hao Y, et al. 2022. Exp Ther Med. 23:350. PubMed
  6. Yang D, et al. 2022. Cell. 185:1905. PubMed
  7. Kataru RP, et al. 2021. Sci Signal. 14:. PubMed
  8. Bruno MEC, et al. 2022. J Cell Physiol. 237:706. PubMed
  9. Friesen M, et al. 2022. Brain Pathol. 32:e13032. PubMed
  10. Zhang C, et al. 2022. Genomics Proteomics Bioinformatics. :. PubMed
  11. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  12. Gadipudi LL, et al. 2022. Clin Sci (Lond). 136:643. PubMed
  13. Guttman O, et al. 2022. J Cell Biol. 221: . PubMed
  14. Van Deren DA, et al. 2022. Development. 149: . PubMed
  15. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  16. Liu X, et al. 2022. Adv Sci (Weinh). 9:e2105650. PubMed
  17. Tsumita T, et al. 2022. Int J Cancer. 151:944. PubMed
  18. Li F, et al. 2022. Gut Microbes. 14:2096989. PubMed
  19. Liu X, et al. 2022. Chin Med J (Engl). 135:1821. PubMed
  20. Li X, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:1077. PubMed
  21. Wu X, et al. 2022. J Clin Med. 11: . PubMed
  22. Zhang Z, et al. 2022. Mol Nutr Food Res. 66:e2200300. PubMed
  23. Li GX, et al. 2022. Int J Biochem Cell Biol. 152:106299. PubMed
  24. Wohlgemuth L, et al. 2022. Cells. 11: . PubMed
  25. Millar FR, et al. 2022. Cell Rep. 41:111596. PubMed
  26. Liu M, et al. 2022. Cells. 11: . PubMed
  27. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  28. Cai S, et al. 2023. J Clin Invest. 133: . PubMed
  29. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  30. Cheng P, et al. 2023. Pharmacol Res. 188:106643. PubMed
  31. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  32. Cagle LA, et al. 2023. Front Physiol. 13:1059686. PubMed
  33. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  34. Zhang L, et al. 2023. J Inflamm Res. 16:109. PubMed
  35. Olivares-González L, et al. 2022. Antioxidants (Basel). 12: . PubMed
  36. Peng Y, et al. 2023. Respir Res. 24:33. PubMed
  37. Wang C, et al. 2023. Exp Mol Med. 55:347. PubMed
  38. Schwartz M, et al. 2023. Nat Microbiol. 8:455. PubMed
  39. Tsioti I, et al. 2023. J Neuroinflammation. 20:25. PubMed
  40. Hattori Y, et al. 2023. Cell Rep. 42:112092. PubMed
  41. Chen Y, et al. 2023. Stem Cells Int. 2023:7482546. PubMed
  42. Lu QK, et al. 2022. Acta Pharmacol Sin. 43:376. PubMed
  43. Liu X, et al. 2022. Pain. 163:508. PubMed
  44. Ryan CB, et al. 2022. Neurobiol Dis. 163:105608. PubMed
  45. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  46. Howard ZM, et al. 2022. Am J Physiol Cell Physiol. 322:C354. PubMed
  47. Ma Y, et al. 2022. Am J Physiol Heart Circ Physiol. 322:H622. PubMed
  48. Leick MB, et al. 2022. Cancer Cell. 40:494. PubMed
  49. Pulous FE, et al. 2022. Nat Neurosci. 25:567. PubMed
  50. Pfeifhofer-Obermair C, et al. 2022. Bio Protoc. 12:e4378. PubMed
  51. Bruggemann TR, et al. 2022. iScience. 25:105185. PubMed
  52. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  53. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  54. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  55. Chen Q, et al. 2019. Cell Stem Cell. 25(6):768-783.e6. PubMed
  56. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  57. Frieler RA, et al. 2017. Exp Neurol. 298:104. PubMed
  58. Combes F, et al. 2018. Neoplasia. 20:848. PubMed
  59. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  60. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  61. Jiang W, et al. 2017. Sci Rep. 7:6501. PubMed
  62. Schröder N, et al. 2020. J Neuroinflammation. 17:131. PubMed
  63. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  64. Abdel-Haq R, et al. 2022. Elife. 11:. PubMed
  65. Zhang Y, et al. 2023. Invest Ophthalmol Vis Sci. 64:1. PubMed
  66. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  67. Zhang X, et al. 2023. Heliyon. 9:e13490. PubMed
  68. Zhong WJ, et al. 2023. J Transl Med. 21:179. PubMed
  69. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  70. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  71. Rundberg Nilsson A, et al. 2023. iScience. 26:106341. PubMed
  72. Palakurthi B, et al. 2023. Nat Commun. 14:2109. PubMed
  73. Silva BM, et al. 2023. J Clin Invest. 133:. PubMed
  74. Duan JL, et al. 2023. Nat Aging. 3:258. PubMed
  75. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  76. Yu PC, et al. 2023. Pharmaceuticals (Basel). 16:. PubMed
  77. Arora S, et al. 2023. PLoS One. 18:e0286211. PubMed
  78. Kase N, et al. 2023. Front Cell Dev Biol. 11:1022081. PubMed
  79. Tsugawa H, et al. 2023. PLoS Pathog. 19:e1011139. PubMed
  80. Fixsen BR, et al. 2023. Nat Immunol. . PubMed
  81. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  82. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  83. d'Errico P, et al. 2021. Nat Neurosci. Online ahead of print. PubMed
  84. Huck NA, et al. 2021. J Neurosci. 41:4349. PubMed
  85. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  86. Almada AE, et al. 2021. Cell Reports. 34(4):108656. PubMed
  87. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  88. Oliveira-Lima OC, et al. 2015. Immunobiology. . PubMed
  89. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  90. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  91. Page N, et al. 2018. Immunity. 48:937. PubMed
  92. Frisbee AL, et al. 2019. Nat Commun. 10:2712. PubMed
  93. Sanders KA, et al. 2019. Sci Rep. 9:231. PubMed
  94. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  95. Wang F, et al. 2018. Oncogenesis. 7:41. PubMed
  96. Hanhai Z, et al. 2021. Aging (Albany NY). 13:13108. PubMed
  97. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  98. Hewitson JP, et al. 2020. J Immunol. 204:2949. PubMed
  99. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  100. Boldison J, et al. 2020. Cell Mol Immunol. 17:843. PubMed
  101. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  102. Skinner DD, et al. 2022. Front Immunol. 13:931388. PubMed
  103. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  104. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  105. O’Dea K, et al. 2016. PLoS One. 11:e0167801. PubMed
  106. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  107. Ebneter A, et al. 2017. Transl Vis Sci Technol. 10.1167/tvst.6.2.10. PubMed
  108. Chen Y, et al. 2018. EBioMedicine. 32:31. PubMed
  109. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  110. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  111. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  112. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  113. Oh DS, et al. 2021. Autophagy. 17:2111. PubMed
  114. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  115. Jia G, et al. 2022. Front Cell Dev Biol. 9:796757. PubMed
  116. Rogic A, et al. 2021. Nat Commun. 12:6889. PubMed
  117. Rossi DC, et al. 2021. J Clin Invest. 131:. PubMed
  118. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  119. Larouche JA, et al. 2021. eLife. 0.416666666666667. PubMed
  120. Yousif AS, et al. 2020. Immunity. 54(2):235-246.e5. PubMed
  121. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  122. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  123. Lutzmann M, et al. 2019. Cell Rep. 28:2851. PubMed
  124. Chow MT et al. 2019. Immunity. 50(6):1498-1512 . PubMed
  125. Chattopadhyay A, et al. 2018. Sci Rep. 8:9032. PubMed
  126. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  127. Bae SH, et al. 2021. Theranostics. 11:2522. PubMed
  128. Mathur S, et al. 2021. JCI Insight. 6:. PubMed
  129. Kummer MP, et al. 2021. EMBO J. 40:e108662. PubMed
  130. Casali P, et al. 2021. Front Immunol. 12:761450. PubMed
  131. Xu M, et al. 2021. Front Physiol. 12:700338. PubMed
  132. Bell BJ, et al. 2022. Brain Behav Immun Health. 23:100478. PubMed
  133. Dolgova EV, et al. 2022. Int J Mol Sci. 23:. PubMed
  134. Xiong A, et al. 2022. EBioMedicine. 83:104239. PubMed
  135. Castiglioni A, et al. 2015. PLoS One. 10:128094. PubMed
  136. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  137. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  138. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  139. Seita Y, et al. 2020. J Alzheimers Dis. 75:45:00. PubMed
  140. Shi L, et al. 2021. Immunity. . PubMed
  141. Jin X, et al. 2019. Mol Cell. 73:22:00. PubMed
  142. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  143. Yamashiro LH, et al. 2020. Nat Commun. 2.806944444. PubMed
  144. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  145. Zhang X, et al. 2022. Pharmaceutics. 14:. PubMed
  146. Higa T, et al. 2022. Nat Commun. 13:1500. PubMed
  147. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  148. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  149. Lebratti T, et al. 2021. eLife. 10:00. PubMed
  150. Chew W, et al. 2016. Nat Methods. 13: 868-874. PubMed
  151. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  152. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  153. Sive J, et al. 2015. Leukemia. . PubMed
  154. Eddens T, et al. 2015. J Immunol. 195: 185 - 193. PubMed
  155. Haas R 2013. J Immunol. 190:3100. PubMed
  156. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  157. An YA et al. 2017. eLife. 6 pii: e24071. PubMed
  158. Nowak WN, et al. 2019. Mediators Inflamm. 2019:1868170. PubMed
  159. Tran L, et al. 2017. Cancer Immunol Res. 5:1141. PubMed
  160. Nakamura‐Ishizu A et al. 2018. Cell reports. 25(7):1772-1785 . PubMed
  161. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  162. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  163. Donlan AN, et al. 2020. Anaerobe. 66:102275. PubMed
  164. Hug S, et al. 2021. Front Immunol. 12:642867. PubMed
  165. Xiao P, et al. 2021. JCI Insight. 6:. PubMed
  166. Yu X, et al. 2022. J Extracell Vesicles. 11:e12185. PubMed
  167. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  168. Zhou Y, et al. 2022. Nat Commun. 13:2906. PubMed
  169. Kumari A, et al. 2022. Sci Rep. 12:15273. PubMed
  170. Li P, et al. 2021. Nat Immunol. 22:1107. PubMed
  171. Uher O, et al. 2021. Cancers (Basel). 13:. PubMed
  172. Callahan SM, et al. 2021. Curr Protoc. 1:e294. PubMed
  173. Yoshida K, et al. 2022. Sci Rep. 12:17276. PubMed
  174. Syed A, et al. 2015. Infect Immun . 83: 3428-3437. PubMed
  175. Gabbita S, et al. 2015. PLoS One. 10: e0137305. PubMed
  176. Zhang Y, et al. 2020. Int J Mol Sci. 21:00. PubMed
  177. Szafran BN, et al. 2021. Chemical Research in Toxicology. 34(6):1556-1571. PubMed
  178. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  179. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  180. Yang L, et al. 2020. Cell Stem Cell. 27(1):125-136. PubMed
  181. Sato H, et al. 2020. Cell Reports. 31(5):107579. PubMed
  182. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  183. Sodji QH, et al. 2022. Cancer Res Commun. 2:725. PubMed
  184. Li Z, et al. 2022. J Exp Clin Cancer Res. 41:74. PubMed
  185. Hu J, et al. 2022. Cell Mol Neurobiol. . PubMed
  186. Soto-Díaz K, et al. 2021. Front Immunol. 12:734349. PubMed
  187. Scheiblich H, et al. 2021. J Immunol. 207:2143. PubMed
  188. Shcherbina A, et al. 2020. Cell Rep. 32:107964. PubMed
  189. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  190. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  191. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  192. Chun E, et al. 2020. Immunity. 51(5):871-884.e6.. PubMed
  193. Di Genua C, et al. 2020. Cancer Cell. 37(5):690-704.e8.. PubMed
  194. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
  195. Hiramoto T, et al. 2018. Mol Ther. 26:1255. PubMed
  196. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  197. Topper MJ et al. 2017. Cell. 171(6):1284-1300 . PubMed
  198. Yu VWC, et al. 2017. Cell. 168:944. PubMed
  199. Ayoub M, et al. 2019. Sci Rep. 9:6348. PubMed
  200. Perdomo J, et al. 2019. Nat Commun. 10:1322. PubMed
  201. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  202. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  203. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  204. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  205. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  206. BÖiers C, et al. 2018. Dev Cell. 44:362. PubMed
  207. Timmons GA, et al. 2021. Front Immunol. 12:700431. PubMed
  208. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  209. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  210. Lee SS, et al. 2022. Commun Biol. 5:654. PubMed
  211. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  212. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  213. Pitsch J, et al. 2021. Ann Neurol. 89:666. PubMed
  214. Hu J, et al. 2022. J Neuroinflammation. 19:71. PubMed
  215. Miki Y, et al. 2016. J Biol Chem. 291: 15588 - 15601. PubMed
  216. Liu Y, et al. 2017. J Neurosci. 37(4):871-881. PubMed
  217. Li J, et al. 2020. Elife. 9:00. PubMed
  218. Wessel AW, et al. 2020. Nat Commun. 4.123611111. PubMed
  219. Callahan S, et al. 2020. Cell Microbiol. 22:e13210. PubMed
  220. Tang CC, et al. 2021. eLife. 10:00. PubMed
  221. Li Y, et al. 2020. Cell Stem Cell. 27(5):732-747.e7. PubMed
  222. Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
  223. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  224. Morimura S, et al. 2021. Int J Mol Sci. :22. PubMed
  225. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  226. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  227. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  228. Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed
  229. Zhou Z, et al. 2022. Life (Basel). 12:. PubMed
  230. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  231. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  232. Yang Z, et al. 2021. Sci Adv. 7:. PubMed
  233. Shen X, et al. 2021. Front Immunol. 12:710750. PubMed
  234. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  235. Kren N, et al. 2020. Sci Rep. 10:7390. PubMed
  236. Viengkhou B, et al. 2021. J Neuroinflammation. 18:237. PubMed
  237. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  238. Hassan AO, et al. 2021. Cell Reports. 36(4):109452. PubMed
  239. Zee BM, et al. 2021. iScience. 24(6):102651. PubMed
  240. Nguyen PT, et al. 2020. Cell. 182(2):388-403.e15. PubMed
  241. Bayik D, et al. 2020. Cancer Discov. 1.256944444. PubMed
  242. Corrales L, et al. 2016. J Immunol. 196: 3191-3198. PubMed
  243. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  244. Yu LC, et al. 2020. Front Neurol. 1.104166667. PubMed
  245. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  246. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  247. Haloul M, et al. 2019. Sci Rep. 9:14050. PubMed
  248. Booth CAG, et al. 2018. Cancer Cell. 33:274. PubMed
  249. Xu X, et al. 2018. Cell. 175:1336. PubMed
  250. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  251. Ishidome T et al. 2017. EBioMedicine. 22:89-99 . PubMed
  252. Ruan C, et al. 2020. Brain Behav Immun. 83:180. PubMed
  253. Lu P, et al. 2021. Nat Commun. 12:1042. PubMed
  254. Bugler-Lamb AR, et al. 2021. Mol Metab. 49:101197. PubMed
  255. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  256. Yan W, et al. 2021. Front Med (Lausanne). 8:752223. PubMed
  257. Kim S, et al. 2021. Elife. 10:. PubMed
  258. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  259. Cuesta M, et al. 2016. J Immunol. 196: 2466 - 2475. PubMed
  260. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  261. Nosho S, et al. 2020. Int J Mol Sci. 21:00. PubMed
  262. Runyan CE, et al. 2020. Aging Cell. 19:00. PubMed
  263. Burns JC, et al. 2020. eLife. 9:00. PubMed
  264. Tripathi H, et al. 2020. Stem Cell Rev Rep. 0.953472222. PubMed
  265. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  266. Sauma D, et al. 2017. Immunol Res. 10.1007/s12026-017-8936-9. PubMed
  267. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  268. Milner MT, et al. 2022. STAR Protoc. 3:101295. PubMed
  269. Zelter T, et al. 2022. EMBO Rep. 23:e53641. PubMed
  270. Zhang X, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Otvos B, et al. 2021. Clin Cancer Res. 27:2038. PubMed
  272. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  273. Ye X, et al. 2021. Cancer Biol Med. Online ahead of print. PubMed
  274. Cilenti F, et al. 2021. Immunity. . PubMed
  275. Maruoka M, et al. 2021. Molecular Cell. 81(7):1397-1410.e9. PubMed
  276. Lee J, et al. 2020. Cell Reports. 33(13):108560. PubMed
  277. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  278. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  279. Cho DS, et al. 2020. J Cachexia Sarcopenia Muscle. 1.396527778. PubMed
  280. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  281. Liu Z, et al. 2020. Cell. 178(6):1509-1525.e19.. PubMed
  282. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  283. Xia P et al. 2018. Immunity. 48(4):688-701 . PubMed
  284. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  285. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  286. Li W, et al. 2021. Cell Transplant. 30:9636897211004090. PubMed
  287. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  288. Vasudevan SO, et al. 2022. Cell Rep. 39:110755. PubMed
  289. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  290. Wolf SJ, et al. 2022. JCI Insight. 7:. PubMed
  291. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  292. Huang J, et al. 2014. J Immunol. 192:1972. PubMed
  293. Xiong X, et al. 2015. Stroke. 46: 2271-2276. PubMed
  294. Zhang L, et al. 2021. iScience. 24(9):102942. PubMed
  295. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  296. Sun J et al. 2018. Cell stem cell. 23(3):355-369 . PubMed
  297. Goldstein JM et al. 2019. Cell reports. 27(4):1254-1264 . PubMed
  298. Ford J, et al. 2019. Front Immunol. 2.502083333. PubMed
  299. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  300. Akk A, et al. 2019. Mol Immunol. 114:629. PubMed
  301. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  302. Howard ZM, et al. 2022. JCI Insight. 7:. PubMed
  303. Gavini CK, et al. 2022. J Neuroinflammation. 19:57. PubMed
  304. McCallion A, et al. 2022. Front Immunol. 13:961599. PubMed
  305. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  306. Mohammadi MR, et al. 2021. Commun Biol. 4:685. PubMed
  307. Chen R, et al. 2021. Cell Reports. 34(7):108751. PubMed
  308. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  309. León-Cabrera S, et al. 2014. Int J Biol Sci. 9 948 . PubMed
  310. Johansson J, et al. 2013. J Neurosci. 33:16016. PubMed
  311. Hohsfield LA, et al. 2020. J Neuroinflammation. 0.902083333. PubMed
  312. Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed
  313. Tang Y, et al. 2019. Nat Commun. 10:4157. PubMed
  314. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  315. Duarte D, et al. 2018. Cell Stem Cell. 22:64. PubMed
  316. Nenasheva T, et al. 2017. PLoS One. 12(6):e0178983. PubMed
  317. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  318. Deng Q, et al. 2021. Gut Microbes. 13:1. PubMed
  319. Kataru RP, et al. 2022. Front Aging. 3:864860. PubMed
  320. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  321. Yang YS, et al. 2022. Nat Commun. 13:6175. PubMed
  322. Gorina R, et al. 2014. J Immunol. 192:324. PubMed
  323. Liu Y, et al. 2015. BioMed Res Int. 2015 563425. PubMed
  324. Choi J, et al. 2015. PLoS One. 10: e0138592. PubMed
  325. Jaako P, et al. 2016. Leukemia. 10.1038/leu.2016.159. PubMed
  326. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  327. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  328. Uribe-Herranz M, et al. 2018. JCI Insight. 3. PubMed
  329. Vásquez M, et al. 2019. J Immunol. 203:696. PubMed
  330. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  331. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  332. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  333. Liu X, et al. 2021. Int J Med Sci. 18:3125. PubMed
  334. Friker LL, et al. 2020. Cell Rep. 30:3743. PubMed
  335. Chen F, et al. 2021. J Cell Mol Med. 25:11039. PubMed
  336. Howard ZM, et al. 2021. Am J Pathol. 191:730. PubMed
  337. Luciunaite A, et al. 2020. J Neurochem. 155:650. PubMed
  338. Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed
  339. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  340. van Geffen C, et al. 2021. Front Immunol. 12:695933. PubMed
  341. Milich LM, et al. 2021. J Exp Med. 218:. PubMed
  342. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  343. Vaibhav K, et al. 2020. Sci Adv. 6:eaax8847. PubMed
  344. Prislovsky A, Strom T 2013. Exp Hematol. 41:789. PubMed
  345. Kajiwara C, et al. 2018. J Immunol. 200:623. PubMed
  346. Gomes T, et al. 2019. Front Immunol. 10:2088. PubMed
  347. Ombrato L, et al. 2021. Nat Protoc. 16:872. PubMed
  348. Kelley WJ, et al. 2022. JCI Insight. 7: . PubMed
  349. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  350. Jia Y, et al. 2022. Cell Discov. 8:21. PubMed
  351. Takeda K, et al. 2014. Am J Pathol. 184:686. PubMed
  352. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  353. Cerina M, et al. 2017. Brain Behav Immun. 59:103-117. PubMed
  354. Messerer DAC, et al. 2020. Front Immunol. 11:571992. PubMed
  355. Markworth JF, et al. 2020. JCI Insight. 5:00. PubMed
  356. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  357. Chung S, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L921:318. PubMed
  358. Steinkühler J, et al. 2018. J Cell Sci. 132. PubMed
  359. Haruwaka K, et al. 2019. Nat Commun. 4.455555556. PubMed
  360. Ireland L, et al. 2020. Front Immunol. 11:297. PubMed
  361. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  362. Fan HH, et al. 2021. Methods Mol Biol. 2276:203. PubMed
  363. Chavez JS, et al. 2022. Cells. 11:. PubMed
  364. Gao P, et al. 2021. Nat Commun. 1194:12. PubMed
  365. Ubags ND, et al. 2021. J Allergy Clin Immunol. 1049:147. PubMed
  366. Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed
  367. Riedel SS, et al. 2021. Molecular Cell. 81(11):2332-2348.e9. PubMed
  368. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  369. Fukasawa K, et al. 2016. Sci Rep. 6:30918. PubMed
  370. Andresen L, et al. 2016. PLoS One. 11: 0148428. PubMed
  371. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  372. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  373. Shi Y, et al. 2015. Mol Immunol. 66: 208-215. PubMed
  374. Tr änkner D, et al. 2019. Cell Rep. 29:791. PubMed
  375. Kunishita Y, et al. 2020. Front Immunol. 11:98. PubMed
  376. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  377. Nguyen HX et al. 2017. J Neurosci. 37(38):9269-9287 . PubMed
  378. Schroder WA, et al. 2019. Sci Rep. 9:12421. PubMed
  379. Wang C, et al. 2018. Sci Transl Med. 10. PubMed
  380. Nakamura K, et al. 2018. Cancer Cell. 33:634. PubMed
  381. Zhang B, et al. 2021. Nature. 599:471. PubMed
  382. Jones GS, et al. 2020. mSphere. 5:. PubMed
  383. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  384. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  385. Zha ZX, et al. 2022. Acta Pharmacol Sin. :. PubMed
  386. Zhang H, et al. 2022. Commun Biol. 5:916. PubMed
  387. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  388. Shen L, et al. 2021. Cell Metabolism. 33(5):971-987.e6. PubMed
  389. Thurlow LR, et al. 2018. Cell Host Microbe. 24:261. PubMed
  390. Petriello MC, et al. 2018. Toxicol Sci. 162:548. PubMed
  391. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  392. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  393. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  394. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  395. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  396. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  397. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  398. Zhong J, et al. 2021. Commun Biol. 4:865. PubMed
  399. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  400. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  401. Ren X, et al. 2021. Cell Death Dis. 12:484. PubMed
  402. Du Z, et al. 2020. J Allergy Clin Immunol. . PubMed
  403. Li X, et al. 2021. Cell Reports. 36(8):109607. PubMed
  404. Li J, et al. 2021. eLife. 10:00. PubMed
  405. Wan Y, et al. 2020. Cell Rep. 33:108346. PubMed
  406. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  407. Xie Y, et al. 2020. Endocrinology. 161:00:00. PubMed
  408. Hohmann A, et al. 2016. Nat Chem Biol. 10.1038/nchembio.2115. PubMed
  409. Ramos-Sevillano E, et al. 2016. PLoS One. 12: 1005500. PubMed
  410. Kolan S, et al. 2015. PLoS One. 10: 0134113. PubMed
  411. Iwata-Yoshikawa N, et al. 2014. J Virol. 88:8597. PubMed
  412. Ma Y, et al. 2020. Front Immunol. 11:586685. PubMed
  413. Guenther C, et al. 2019. Front Immunol. 10:1138. PubMed
  414. Guarnerio J, et al. 2018. Nat Commun. 9:66. PubMed
  415. Li B, et al. 2019. Oncogenesis. 8:17. PubMed
  416. Omenetti S, et al. 2019. Immunity. 51:77. PubMed
  417. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
RRID
AB_312794 (BioLegend Cat. No. 101211)
AB_312794 (BioLegend Cat. No. 101212)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD11b
Specificity Alt (DOES NOT SHOW ON TDS):
CD11b
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about CD11b on UniProt.org

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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