Purified anti-human CD18 Antibody anti-CD18

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Clone: 1B4/CD18 (See other available formats)
Regulatory Status: RUO
Other Names: Integrin beta-2, integrin beta chain, beta 2
Isotype: Mouse IgG2a, κ
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Product Citations: publications

1B4slashCD18_PURE_CD18_Antibody_022317 — Human peripheral blood lymphocytes were stained with purified CD18 (clone 1B4/CD18) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram) followed by PE Goat anti-mouse IgG.

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373402

100 µg

90€

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Description

CD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains function in adhesion and signaling in hematopoietic cells.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human peripheral blood lymphocytes
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: The 1B4/CD18 antibody was able to partially block the Ts1/18 antibody, indicating the two anti-CD18 antibodies recognize distinct but overlapping epitopes.
RRID: AB_2650942 (BioLegend Cat. No. 373402)

Antigen Details

Structure: Integrin, type I transmembrane glycoprotein
Distribution: Leukocytes
Function: Adhesion and signaling in hematopoietic cells
Interaction: Associates with CD11a, CD11b, or CD11c
Ligand/Receptor: ICAMs
Cell Type: Leukocytes, Tregs
Biology Area: Cell Adhesion, Cell Biology, Immunology, Signal Transduction
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Hogg N, et al. 1999. J. Clin. Invest. 103:97.
2. Anderson DC, et al. 1987. Annu. Rev. Med. 38:175.
3. Springer TA. 1994. Cell 76:301.
Gene ID: 3689 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):: CD18
Specificity Alt (DOES NOT SHOW ON TDS):: CD18
App Abbreviation (DOES NOT SHOW ON TDS):: FC
UniProt: View information about CD18 on UniProt.org

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Description	Clone	Applications
Purified anti-human CD18	1B4/CD18	FC
APC anti-human CD18	1B4/CD18	FC
PE/Cyanine7 anti-human CD18	1B4/CD18	FC
Alexa Fluor® 488 anti-human CD18	1B4/CD18	FC
PE anti-human CD18	1B4/CD18	FC

Certificate of Analysis

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Go To Top Version: 0 Revision Date: 03/16/2017

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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