- Clone
- QA17A09 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- c-KIT, Stem Cell Factor Receptor, SCFR
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
155109 | 50 µg | 203€ |
CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Murine IL-3 dependent mast cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
- RRID
-
AB_2800691 (BioLegend Cat. No. 155109)
Antigen Details
- Structure
- Growth factor receptor, tyrosine kinase
- Distribution
-
Hematopoietic stem cells, AML, mast cells, oocytes, interstitial theca cells, leydig cells
- Function
- Growth factor receptor, tyrosine kinase
- Ligand/Receptor
- Stem Cell Factor (SCF)
- Cell Type
- Hematopoietic stem and progenitors, Leukemia, Mast cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Barclay AN, Brown MH. 1997. Biochem. Soc. Trans. 25:224-8.
- Galli SJ, et al. 1994. Adv. Immunol. 55:1.
- Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759.
- Besmer P, et al. 1986. Nature. 320:415-21.
- Witte ON. 1990. Cell. 63:5.
- Gene ID
- 16590 View all products for this Gene ID
- UniProt
- View information about CD117 on UniProt.org
Related FAQs
- What is the F/P ratio range of our BV421™ format antibody reagents?
-
It is lot-specific. On average it ranges between 2-4.
Other Formats
View All CD117 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse CD117 (c-kit) Recombinant Antibody | QA17A09 | FC |
PE anti-mouse CD117 (c-kit) Recombinant Antibody | QA17A09 | FC |
APC anti-mouse CD117 (c-kit) Recombinant Antibody | QA17A09 | FC |
FITC anti-mouse CD117 (c-kit) Recombinant Antibody | QA17A09 | FC |
Brilliant Violet 421™ anti-mouse CD117 (c-kit) Recombinant Antibody | QA17A09 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-mouse CD117 (c-kit) Recombinant Antibody
C57BL/6 mouse bone marrow cells were stained with CD11b APC ... -
PE anti-mouse CD117 (c-kit) Recombinant Antibody
C57BL/6 mouse bone marrow cells were stained with CD11b APC ... -
APC anti-mouse CD117 (c-kit) Recombinant Antibody
C57BL/6 mouse bone marrow cells were stained with CD11b PE a... -
FITC anti-mouse CD117 (c-kit) Recombinant Antibody
C57BL/6 mouse bone marrow cells were stained with CD11b APC ... -
Brilliant Violet 421™ anti-mouse CD117 (c-kit) Recombinant Antibody
C57BL/6 mouse bone marrow cells were stained with CD11b FITC...
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