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PE anti-mouse CD41 Antibody

Pricing & Availability
Clone
MWReg30 (See other available formats)
Regulatory Status
RUO
Other Names
Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
MWREG30_PE_102811
C57 BL/6 platelets were stained with CD41 (clone: MWReg30) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
  • MWREG30_PE_102811
    C57 BL/6 platelets were stained with CD41 (clone: MWReg30) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
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133905 25 µg 58€
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133906 100 µg 173€
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Description

CD41, also known as integrin α2b and GPIIb, is a transmembrane glycoprotein that is expressed by platelets and megakaryocytes. It was reported that CD41 is also expressed on hematopoietic progenitors. CD41 associates with CD61 (integrin β3) to form complexes that interact with fibrinogen, fibronectin, von Willebrand factor, and thrombin. CD41 is required for platelet adhesion and aggregation. Defect of CD41 leads to disorders of coagulation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse platelets
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).

Application References

(PubMed link indicates BioLegend citation)
  1. Nieswandt B, et al. 1999. Blood 94:684.
  2. Teeling JL, et al. 2001. Blood 98:1095.
  3. Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
  4. Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
  5. Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
  6. van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
  7. Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
Product Citations
  1. Tarazi S, et al. 2022. Cell. 185:3290. PubMed
  2. Roweth HG, et al. 2022. Sci Adv. 8:eabo5224. PubMed
  3. Zhou M, et al. 2023. Biomed Pharmacother. 161:114530. PubMed
  4. Rundberg Nilsson A, et al. 2023. iScience. 26:106341. PubMed
  5. Sandovici I, et al. 2022. Dev Cell. 57:63. PubMed
  6. Safi F 2023. STAR Protocols. 4(1):101965. PubMed
  7. Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
  8. Lang J, et al. 2020. Nat Commun. 11:1338. PubMed
  9. Luchsinger LL, et al. 2020. Cell Stem Cell. 25(2):225-240. PubMed
  10. Machata S, et al. 2021. Front Immunol. 11:565869. PubMed
  11. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  12. Wiley CD, et al. 2019. Cell Rep. 28:3329. PubMed
  13. Li Q, et al. 2019. Neuron. 101:207. PubMed
  14. Matsushita Y, et al. 2021. J Bone Miner Res. 36:1145. PubMed
  15. Cummings H, et al. 2013. J Immunol. 191:5807. PubMed
  16. Meng S, et al. 2022. Exp Anim. . PubMed
  17. Iturri L, et al. 2021. Immunity. . PubMed
  18. Wong J, et al. 2015. Elife. 3: 07839. PubMed
  19. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  20. Yeung AK, et al. 2020. Blood Adv. 4:6204. PubMed
  21. Ma L, et al. 2015. Blood. 126: 247 - 256. PubMed
  22. Liu Z, et al. 2016. J Biol Chem. 291: 1441 - 1447. PubMed
  23. Stivala S, et al. 2019. J Clin Invest. 130:1596. PubMed
  24. Wang JD, et al. 2021. Cancers (Basel). :13. PubMed
  25. Elahi S, et al. 2020. Stem Cell Res. 43:101710. PubMed
  26. Yan R, et al. 2021. Cell Death Dis. 12:955. PubMed
  27. Jiang Y, et al. 2021. Cell Death Differ. 28:3009. PubMed
  28. Sevin M, et al. 2018. Nat Commun. 9:1431. PubMed
  29. Bikorimana E, et al. 2014. J Vis Exp. 92: 52022. PubMed
  30. He H, et al. 2020. Sci Adv. 6:00. PubMed
  31. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  32. Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
  33. McVey MJ, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L625. PubMed
  34. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
RRID
AB_2129745 (BioLegend Cat. No. 133905)
AB_2129745 (BioLegend Cat. No. 133906)

Antigen Details

Structure
A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
Distribution

Platelets, megakaryocytes, and hematopoietic progenitors

Function
Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
Ligand/Receptor
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Cell Type
Hematopoietic stem and progenitors, Megakaryocytes, Platelets
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.

Gene ID
16399 View all products for this Gene ID
UniProt
View information about CD41 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 03/19/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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