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PE anti-human Integrin αVβ6 Antibody

Pricing & Availability
Clone
53a.2 (See other available formats)
Regulatory Status
RUO
Other Names
Integrin alpha V beta 6
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
53apt2_PE_alphaVbeta6_Antibody_053024
Human colon carcinoma cell line HT-29 was stained with anti-human Integrin αVβ6 (clone 53a.2) PE (filled histogram) or rat IgG2a, κ PE isotype control (open histogram).
  • 53apt2_PE_alphaVbeta6_Antibody_053024
    Human colon carcinoma cell line HT-29 was stained with anti-human Integrin αVβ6 (clone 53a.2) PE (filled histogram) or rat IgG2a, κ PE isotype control (open histogram).
Compare all formats See PE spectral data
Cat # Size Price Save
384205 25 tests ¥37,840
384206 100 tests ¥75,240
Description

Integrins are heterodimeric transmembrane receptors comprising alpha and beta subunits that function as cell anchoring and signaling molecules. The ITGAV gene encodes integrin alpha V, a type I integral membrane glycoprotein known as the vitronectin receptor α chain, or CD51. It forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. Integrin αV contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Integrin beta 6 is a protein that in humans is encoded by the ITGB6 gene. The β6 subunit only combines with αV to generate a single heterodimer. Integrin αVβ6 is a subtype of the integrin family expressed exclusively on epithelial cells. Integrin αVβ6 is usually expressed at low or undetectable levels in normal adult tissues but can be highly upregulated during pathological and physiological processes such as wound healing, fibrosis, inflammation, and cancer.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Marsh D, el al. 2008. Cancer Res. 68:3295.
RRID
AB_3106248 (BioLegend Cat. No. 384205)
AB_3106248 (BioLegend Cat. No. 384206)

Antigen Details

Distribution

Epithelial cells

Function
Modulate innate immune surveillance, maintain epithelial stem cell quiescence
Ligand/Receptor
Serve as a fibronectin receptor
Cell Type
Epithelial cells
Biology Area
Angiogenesis, Cell Adhesion
Molecular Family
Adhesion Molecules
Gene ID
3685 View all products for this Gene ID 3694 View all products for this Gene ID
UniProt
View information about Integrin alphaVbeta6 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 05/30/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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