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PE/Cyanine7 anti-mouse CD38 Antibody

Pricing & Availability
Clone
90 (See other available formats)
Regulatory Status
RUO
Other Names
T10
Isotype
Rat IgG2a, κ
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Product Citations
publications
90_PECy7_011108
C57BL/6 mouse splenocytes stained with 90 PE/Cyanine7
  • 90_PECy7_011108
    C57BL/6 mouse splenocytes stained with 90 PE/Cyanine7
Compare all formats See PE/Cyanine7 spectral data
Cat # Size Price Save
102717 25 µg ¥23,320
102718 100 µg ¥71,060
Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow pre-B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
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  13. Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed
  14. Degn SE et al. 2017. Cell. 170(5):913-926 . PubMed
  15. Shi B, et al. 2018. J Immunol. 200:586. PubMed
  16. Bauer KM, et al. 2022. JCI Insight. 7:. PubMed
  17. Chen J et al. 2018. Cell reports. 25(12):3393-3404 . PubMed
  18. Kim CC et al. 2019. Cell Rep. 27(5):1446-1460 . PubMed
  19. Jia X, et al. 2021. Clin Transl Immunology. 10:e1336. PubMed
  20. Juul-Madsen K, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  21. Muppidi J, et al. 2015. J Exp Med. 212: 2213 - 2222. PubMed
  22. Hilpert C, et al. 2016. J Immunol. 197: 2780 - 2786. PubMed
  23. Ly A, et al. 2020. Cell Reports. 29(8):2257-2269.e6.. PubMed
  24. Sato R, et al. 2020. Int Immunol. 499:32. PubMed
  25. Duan L, et al. 2021. Immunity. 54:2256. PubMed
  26. Mintz MA, et al. 2019. Immunity. 51:310. PubMed
  27. Ise W, et al. 2018. Immunity. 48:702. PubMed
  28. Barsoumian HB, et al. 2020. J Immunother Cancer. 8:00. PubMed
  29. Abbott RK, et al. 2018. Immunity. 48:133. PubMed
  30. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  31. Huang D, et al. 2020. Nat Commun. 4.520833333. PubMed
  32. Hilpert C, et al. 2019. J Immunol. 203:3068. PubMed
  33. Alexandre YO, et al. 2020. Cell Reports. 33(13):108567. PubMed
  34. Kajikawa A, et al. 2015. PLoS One. 10: e0141713. PubMed
  35. Riedel R, et al. 2020. Nat Commun. 11:2570. PubMed
  36. Firl DJ et al. 2018. eLife. 7 pii: e33051. PubMed
  37. Haniuda K, et al. 2020. Cell Rep. 33:108333. PubMed
  38. Teo TH, et al. 2018. Nat Commun. 9:3905. PubMed
  39. Andersen TK, et al. 2019. NPJ Vaccines. 4:9. PubMed
  40. Andersen TK, et al. 2021. Front Immunol. 12:747032. PubMed
  41. van der Poel CE, et al. 2019. Cell Rep. 29:2745. PubMed
  42. Kaji T, et al. 2012. J Exp Med. 209:2079. PubMed
  43. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  44. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  45. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
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  47. Ryg-Cornejo V, et al. 2016. Cell Rep. 14:68-81. PubMed
  48. Smith LK, et al. 2021. Elife. 10:. PubMed
  49. Mesin L, et al. 2020. Cell. 180(1):92-106.e11.. PubMed
  50. Zhang B, et al. 2021. Nature. 599:471. PubMed
  51. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  52. Yu M, et al. 2012. Proc Natl Acad Sci U S A. 109:E879. PubMed
  53. Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed
  54. Trindade BC, et al. 2021. Immunity. 54:2273. PubMed
  55. Song W, et al. 2022. Immunity. 55:290. PubMed
  56. Li X, et al. 2021. Front Immunol. 12:779560. PubMed
RRID
AB_2072892 (BioLegend Cat. No. 102717)
AB_2072892 (BioLegend Cat. No. 102718)

Antigen Details

Structure
ADP-ribosyl hydrolase, 42 kD
Distribution

B cells, NK cells, T cell subset, brain, muscle, kidney

Function
Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor
CD31, hyaluronic acid
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Shubinsky G, et al. 1997. Immunity 7:315.
3. Cesano A, et al. 1998. J. Immunol. 160:1106.
4. Cockayne DA, et al. 1998. Blood 92:1324.

Gene ID
12494 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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