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Purified anti-human CD11c Antibody

Pricing & Availability
Clone
Bu15 (See other available formats)
Regulatory Status
RUO
Workshop
V S143
Other Names
Integrin αx subunit, ITGAX, CR4, p150
Isotype
Mouse IgG1, κ
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Product Citations
publications
Bu15_Pure_110308.jpg
Human peripheral blood granulocytes stained with purified Bu15, followed by anti-mouse IgG FITC
  • Bu15_Pure_110308.jpg
    Human peripheral blood granulocytes stained with purified Bu15, followed by anti-mouse IgG FITC
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Cat # Size Price Save
337202 100 µg ¥24,640
Description

CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes.

Application References

(PubMed link indicates BioLegend citation)
  1. Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42.
  2. Rezzonico R, et al. 2001. Blood 97:2932.
  3. Sadhu C, et al. 2007. J. Leukoc. Biol. 81:1395.
  4. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
Product Citations
  1. Alpert A, et al. 2022. Cell Syst. 13:71. PubMed
  2. Leader AM, et al. 2021. Cancer Cell. 39:1594. PubMed
  3. McIlwain DR, et al. 2021. Cell Host Microbe. 29:1828. PubMed
  4. McCarthy EE, et al. 2022. Cell Rep. 39:110815. PubMed
  5. Feyaerts D, et al. 2022. Cell Rep Med. 3:100680. PubMed
  6. Martin–Fernandez M, et al. 2020. Cell Reports. 31(6):107633. PubMed
  7. Taft J, et al. 2021. Cell. 184(17):4447-4463.e20. PubMed
  8. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  9. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  10. Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
  11. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  12. Gruber CN, et al. 2020. Cell. 183:982. PubMed
  13. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  14. Henrick BM, et al. 2021. Cell. . PubMed
  15. Newell KL, et al. 2021. PLoS One. 16:e0244855. PubMed
  16. NULL, et al. 2022. Cell. 185:916. PubMed
  17. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  18. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
RRID
AB_1236381 (BioLegend Cat. No. 337202)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 145-150 kD
Distribution

Myeloid, dendritic cells, NK cells, B cells and T cell subsets

Function
Adhesion, CTL killing Ligand Receptor: CD54, fibrinogen, iC3b, ICAM-1, ICAM-4 Antigen
Cell Type
B cells, Dendritic cells, Neutrophils, NK cells, T cells
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Petty H. 1996. Immunol. Today 17:209.
2. Springer T. 1994. Cell 76:301.
3. Ihanus E, et al. 2007. Blood 109:802-810.

Gene ID
3687 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 02/14/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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