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- Clone
- W16093B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- IL-27RA, WSX-1, TCCR
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with anti-human CD4 Brilliant Violet 421™ and purified anti-human IL-27Rα (clone W16093B) (left) or mouse IgG1, κ isotype control (right) followed by PE anti-mouse IgG.
69 kD glycosylated transmembrane subunit of IL-27 receptor complex consisting of IL27Ra (WSX-1, TCCR) and gp130 (CD130). Expressed on T cells, monocytes, and neutrophils and aside from its effect on innate immunity, is involved in dampening the extent of Th1 immune response post infection. Activity levels of IFN-γ and IL-17 producing T cells are regulated through this receptor which relays signal through Jak-STAT pathway.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human IL-27Rα transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
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AB_2927976 (BioLegend Cat. No. 384602)
Antigen Details
- Distribution
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T cells, B cells, monocytes
- Function
- γ
- Interaction
- STAT1
- Ligand/Receptor
- IL27Ra combines with gp130 to form a receptor complex whose activation by IL-27 leads to differing pathway-dependent effector activities.
- Cell Type
- Monocytes, Neutrophils, T cells
- Biology Area
- Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Takeda A, et al. 2003. J Immunol. 170:4886-90.
- Yoshida H and Hunter CA. 2015. Annu Rev Immunol. 33:417-43.
- Iwasaki Y, et al. 2015. Int J Mol Sci. 16:2851-63.
- Gene ID
- 9466 View all products for this Gene ID
- UniProt
- View information about IL-27Ralpha on UniProt.org
Other Formats
View All IL-27Rα Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human IL-27Rα | W16093B | FC |
| APC anti-human IL-27Rα | W16093B | FC |
| PE/Cyanine7 anti-human IL-27Rα | W16093B | FC |
| PE anti-human IL-27Rα | W16093B | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human IL-27Rα
Human peripheral blood lymphocytes were stained with anti-hu... -
APC anti-human IL-27Rα
Human peripheral blood lymphocytes were stained with anti-hu... -
PE/Cyanine7 anti-human IL-27Rα
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human IL-27Rα
Human peripheral blood lymphocytes were stained with anti-hu...
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