Purified anti-human TCR Valpha24-Jalpha18 iNKT cell Antibody anti-TCR V alpha 24-J alpha 18

Clone: 6B11 (See other available formats)
Regulatory Status: RUO
Other Names: TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT
Isotype: Mouse IgG1, κ
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Product Citations: publications

Human peripheral blood lymphocytes stained with purified 6B11 conjugated to PE and CD3 (UCHT1) Alexa Fluor® 647 (top) or mIgG1, κ (MOPC-21) PE isotype control and CD3 (UCHT1) Alexa Fluor® 647 (bottom)

Cat #	Size	Price	Save
342902	100 µg	¥27,280

Description

Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Reported Reactivity: Rhesus, Pigtailed Macaque, Sooty Mangabey
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10⁶ cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.
RRID: AB_2229301 (BioLegend Cat. No. 342902)

Antigen Details

Structure: Invariant CDR3 region of TCR Vα24-JαQ
Distribution: Invariant NKT cells
Ligand/Receptor: Glycolipid loaded CD1d
Cell Type: NKT cells
Biology Area: Immunology
Molecular Family: TCRs
Antigen References: Thomas SY, et al. 2003. J. Immunol. 171:2571.

Exley MA, et al. 2008. Eur. J. Immunol. 38:1756.

Montoya CJ, et al. 2007. Immunology. 122:1.

Gansuvd B, et al. 2003. J. Immunol. 171:2904.
Gene ID: 28659 View all products for this Gene ID
UniProt: View information about TCR Valpha24-Jalpha18 on UniProt.org

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Other Formats

View All TCR Vα24-Jα18 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
PE anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
FITC anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
APC anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
PE/Cyanine7 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
PerCP/Cyanine5.5 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
Brilliant Violet 421™ anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
Brilliant Violet 510™ anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
PE/Dazzle™ 594 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
Brilliant Violet 711™ anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
TotalSeq™-A0584 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	PG
TotalSeq™-C0584 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	PG
Brilliant Violet 605™ anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
Brilliant Violet 785™ anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
TotalSeq™-B0584 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	PG
APC/Fire™ 750 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
APC/Cyanine7 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
PerCP/Fire™ 780 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
PerCP/Fire™ 806 anti-human TCR Vα24-Jα18 (iNKT cell)	6B11	FC
Spark Red™ 718 anti-human TCR Vα24-Jα18 (Flexi-Fluor™)	6B11	FC
Spark Blue™ 574 anti-human TCR Vα24-Jα18 (Flexi-Fluor™)	6B11	FC
Spark Blue™ 550 anti-human TCR Vα24-Jα18 (Flexi-Fluor™)	6B11	FC

Certificate of Analysis

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Go To Top Version: 3 Revision Date: 08/30/2022

For Research Use Only. Not for diagnostic or therapeutic use.

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