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- Clone
- RMD3-13 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Delta like 3, M-Delta-3, delta3, drosophila Delta homolog 3
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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OP9-DLL3 transfected cells were fixed, permeabilized, and intracellularly stained with purified DLL3 (clone RMD3-13, solid histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE secondary.
Delta like canonical Notch ligand 3 (DLL3) is consist of a DSL domain, EGF repeats and transmembrane region. Inhibits Notch 1 in its cis format. Involved in embryonic development processes such as T cells development, specifying neuron's fate during neurogenesis and maintaining tissue homeostasis in adults. Potential target for preventing growth of cancer cells in small cell lung cancer.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse DLL3-FC
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Staining for DLL3 using clone RMD3-13 requires fixation and permeabilization. This clone does not work for surface DLL3 staining.
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Application References
(PubMed link indicates BioLegend citation) -
- Murata A, et al. 2014. PLoS One. 9:e108535.
- RRID
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AB_2728210 (BioLegend Cat. No. 154002)
Antigen Details
- Structure
- Type I transmembrane protein with a DSL domain and 6 or 8 EGF-like repeats
- Distribution
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Thymus, Brain
- Function
- Embryogenesis, maintaining tissue homeostasis
- Interaction
- Inhibition of Notch downstream signaling
- Ligand/Receptor
- Notch 1
- Antigen References
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1. Deng S M, et al. 2017. Biochem Biophys Res Commun. 483:488.
2. Shapiro F. 2016. Adv. Anat. Embryol. Cell. Biol. 221:67.
3. Saunders LR, et al. 2015. Sci Transl Med. 7:302.
4. Dvoriantchikova G, et al. 2015. PLoS One. 10:e0131054. - Gene ID
- 13389 View all products for this Gene ID
- UniProt
- View information about DLL3 on UniProt.org
Other Formats
View All Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse DLL3 | RMD3-13 | ICFC |
| PE anti-mouse DLL3 | RMD3-13 | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse DLL3
OP9-DLL3 transfected cells were fixed, permeabilized, and in... -
PE anti-mouse DLL3
Mouse DLL3 transfected OP9 cells were fixed, permeabilized a...
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