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- Clone
- S20012E (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Integrin alpha V beta 6
- Isotype
- Rat IgG2b, λ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Mouse integrin αVβ6 transfected Ba/F3 cells were stained with purified anti-mouse Integrin αVβ6 (clone S20012E) (filled histogram) or purified rat IgG2b, λ isotype control (open histogram) followed by goat anti-rat IgG PE.
Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin β6 associates exclusively with the αV subunit forming an αVβ6 complex that is expressed specifically on epithelial cells. Integrin αVβ6 is a receptor for multiple extracellular matrix (ECM) proteins, including tenascin, fibronectin, and vitronectin. It is also a receptor for the latency-associated peptide (LAP) of TGF-β and is involved in TGF-β activation. Its expression is upregulated during wound healing and in some cancers.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse αVβ6 integrin-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone S20012E does not affect the binding of clone S20012B on target cells.
Clone S20012E does not react with mouse integrin αVβ8. - RRID
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AB_3105985 (BioLegend Cat. No. 166302)
Antigen Details
- Structure
- Integrins
- Distribution
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Epithelial cells
- Function
- Cell adhesion, TGF-β activation
- Cell Type
- Epithelial cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules
- Antigen References
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- Sheppard D, et al 1990. J Biol Chem. 265:11502-7.
- Koivisto L, et al. 2018. Int J Biochem Cell Biol. 99:186-196.
- Gene ID
- 16410 View all products for this Gene ID 16420 View all products for this Gene ID
- UniProt
- View information about Integrin alphaVbeta6 on UniProt.org
Related FAQs
Other Formats
View All integrin αVβ6 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse Integrin αVβ6 | S20012E | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse Integrin αVβ6
Mouse integrin αVβ6 transfected Ba/F3 cells were stained wit...
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