- Clone
- QA18A37 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T8, Leu2
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
---|---|---|---|
303807 | 25 tests | ¥32,340 | |
303808 | 100 tests | ¥82,500 |
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- PROPRIETARY
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Spark YG™ 593 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Spark YG™ 593 has a maximum excitation of 573 nm and a maximum emission of 593 nm. - Excitation Laser
-
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
-
AB_2904332 (BioLegend Cat. No. 303807)
AB_2904332 (BioLegend Cat. No. 303808)
Antigen Details
- Structure
- reIg superfamily, homodimer or heterodimer with CD8b, 32-34 kD
- Distribution
-
Majority of thymocytes, T cell subset, NK cells
- Ligand/Receptor
- MHC Class I molecules
- Cell Type
- NK cells, T cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego.
- Gene ID
- 925 View all products for this Gene ID
- UniProt
- View information about CD8 on UniProt.org
Other Formats
View All CD8 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-human CD8 Recombinant Antibody | QA18A37 | FC |
Spark Violet™ 538 anti-human CD8 Recombinant Antibody | QA18A37 | FC |
Purified anti-human CD8 Recombinant Antibody | QA18A37 | FC |
Spark YG™ 593 anti-human CD8 Recombinant Antibody | QA18A37 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-human CD8 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 APC... -
Spark Violet™ 538 anti-human CD8 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 APC... -
Purified anti-human CD8 Recombinant Antibody
Human peripheral blood lymphocytes were stained with purifie... -
Spark YG™ 593 anti-human CD8 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 Pac...
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